LONG-TERM RESULTS OF WHOLE BLADDER WALL PHOTODYNAMIC THERAPY FOR CARCINOMA IN-SITU OF THE BLADDER
LONG-TERM RESULTS OF WHOLE BLADDER WALL PHOTODYNAMIC THERAPY FOR CARCINOMA IN-SITU OF THE BLADDER
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DOI：
10.1016/s0090-4295(99)80080-6
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发表时间：
1995-05-01
期刊：
影响因子：
2.1
通讯作者：
BAERT, L
中科院分区：
文献类型：
--
作者：
DHALLEWIN, MA;BAERT, L
目标。本文评估了平均随访 3 年后全膀胱壁光动力疗法 (PDT) 治疗多灶性原位癌的结果。方法。 Photofrin II 用作光敏剂 (2 mg/kg) 和原位剂量测定，以获得光扩散器的最佳可能中心定位，并了解准确的剂量测定数据（散射光和非散射光）。结果。 PDT 的主要传统缺点，例如严重的膀胱刺激症状和膀胱收缩，可以在原位剂量测定的帮助下最小化。 3年随访成功率为60%。百分之五十的复发发生在前列腺尿道，没有膀胱疾病的证据。结论。 60% 的成功率与卡介苗 (BCG) 获得的结果相当。通过足够的光剂量测定可以最大程度地减少膀胱容量丧失等副作用，但这些副作用仍然高于卡介苗（9% 与 1% 膀胱切除术）。
Objectives. This article evaluates the results of whole bladder wall photodynamic therapy (PDT) for multifocal carcinoma in situ after a mean follow-up time of 3 years.Methods. Photofrin II was used as a photosensitizer (2 mg/kg) and in situ dosimetry to obtain the best possible central positioning of the light diffuser as well as to know exact dosimetry data (scattered plus nonscattered light).Results. Major classical drawbacks of PDT, such as severe bladder irritative symptoms and bladder shrinking, can be minimized with the help of in situ dosimetry. The success rate after 3-year follow-up is 60%. Fifty percent of the recurrences occurred in the prostatic urethra without evidence of disease of the bladder.Conclusions. A success rate of 60% is comparable to the results obtained after bacille Calmette-Guerin (BCG). Side effects such as loss of bladder capacity can be minimized with adequate light dosimetry but they are still higher than with BCG (9% versus 1% cystectomy).