A virus-mimetic nanogel vehicle
A virus-mimetic nanogel vehicle
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DOI：
10.1002/anie.200704121
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发表时间：
2008-01-01
影响因子：
16.6
通讯作者：
Bae, You Han
中科院分区：
文献类型：
--
作者：
Lee, Eun Seong;Kim, Dongin;Bae, You Han
病毒感染宿主生物体内的特定细胞，复制，破坏细胞，并在感染循环中从细胞传播到细胞，从而引起疾病。[1]这些病毒特性激发了各种递送载体的合成设计，[2-6]特别是对于表现出许多副作用的有毒抗癌剂。药物递送载体通常模仿病毒的方面，例如大小和表面性质，以在被清除之前改善细胞进入和在体内的驻留。[2-6]仿生药物载体设计的最新努力旨在赋予先进的功能。[3]在此，我们描述了一种合成的纳米聚合物载体，其比迄今报道的任何已知的递送系统更显著地模拟病毒特性。这种病毒模拟纳米凝胶（VM-nanogel）应该被证明对于治疗肿瘤等几种主要疾病有价值，并且具有更大的功效。我们开发的VM-nanogel由疏水性聚合物核心和两层亲水性外壳组成（图1）。由聚（L-组氨酸-co-苯丙氨酸）（聚（His 32-co-Phe 6）[4]，其中数字表示嵌段中His和Phe单元的数量）制成的颗粒核心装载有模型抗癌药物多柔比星（DOX）。聚乙二醇（PEG;数均分子量2000 Da）形成内壳。一个PEG末端连接到核心聚合物，另一个连接到牛血清白蛋白（BSA），其形成帽状外壳。[5]核和内壳通过水包油乳液法构建。[2，6]单个BSA分子可以连接到多个PEG末端，如图1所示。表面上的BSA和PEG成分可能有助于避免潜在的免疫反应。[七]《中国日报》
Viruses infect specific cells within host organisms, replicate, destroy the cells, and spread from cell to cell in infectious cycles, thus causing disease.[1] These viral properties have inspired synthetic designs of various delivery vehicles,[2–6] particularly for toxic anticancer agents that exhibit numerous side effects. Drug-delivery vehicles often mimic viral aspects, such as size and surface properties, to improve cell entry and residence within the body before being cleared.[2–6] Recent efforts in biomimetic drug-carrier design have aimed to endow advanced functionality.[3] Herein, we describe a synthetic nanosized polymer vehicle that mimics viral properties more significantly than any known delivery systems so far reported. This virus-mimetic nanogel (VM-nanogel) should prove valuable for treating several major disease classes, such as tumors, with greater efficacy.The VM-nanogel we have developed consists of a hydrophobic polymer core and two layers of hydrophilic shell (Figure 1). A particle core made of poly (L-histidine-co-phenylalanine)(poly (His32-co-Phe6),[4] where the numerals indicate the numbers of His and Phe units in the block) is loaded with a model anticancer drug, doxorubicin (DOX). Polyethylene glycol (PEG; number-average molecular weight 2000 Da) forms the inner shell. One PEG end is linked to the core polymer and another to bovine serum albumin (BSA), which forms a capsid-like outer shell.[5] The core and inner shell were constructed by an oil-in-water emulsion method.[2, 6] A single BSA molecule could be linked to multiple PEG ends, as depicted in Figure 1. The BSA and PEG components on the surface may help to avoid potential immune responses.[7]