ALTERATIONS OF ESTROGEN METABOLISM IN SYSTEMIC LUPUS-ERYTHEMATOSUS
ALTERATIONS OF ESTROGEN METABOLISM IN SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1002/art.1780221106
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发表时间：
1979-01-01
影响因子：
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通讯作者：
FISHMAN, J
中科院分区：
文献类型：
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作者：
LAHITA, RG;BRADLOW, HL;FISHMAN, J
采用尿代谢物测定法，研究了10例系统性红斑狼疮（SLE）患者和29例正常人的雌二醇代谢。SLE患者表现出雌酮的16-羟基化增加。患病男性与患病女性的不同之处在于，男性中仅16α-羟基雌酮升高，而女性中16α-羟基雌酮和雌三醇均升高。这些数据表明，SLE患者具有异常的雌二醇代谢模式，导致雌激素活性增加。
Estradiol metabolism in 10 patients with systemic lupus erythematosus (SLE) and 29 normal controls was studied by measurement of urinary metabolites after injection of labeled3H‐estradiol. Patients with SLE manifested increased 16‐hydroxylation of estrone. Diseased men differed from diseased women to the extent that only 16α‐hydroxyestrone was elevated in men, whereas women had elevations of both 16α‐hydroxyestrone and estriol. These data suggest that patients with SLE have abnormal patterns of estradiol metabolism, leading to increased estrogenic activity.