Specificity in reactive oxidant signaling: think globally, act locally.
Specificity in reactive oxidant signaling: think globally, act locally.
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DOI：
10.1083/jcb.200605036
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发表时间：
2006-08-28
影响因子：
7.8
通讯作者：
Terada, Lance S
中科院分区：
文献类型：
--
作者：
Terada, Lance S
尽管活性氧化剂长期以来一直被认为是不需要的代谢副产物，但在后生动物和植物进化过程中，以受调控的方式特异性产生这些相同分子的氧化酶的表达却令人惊讶地普遍存在。尽管氧化剂参与许多信号传导途径已有充分记录，但赋予此类反应分子途径特异性的细胞策略仍然更加神秘。 Recent studies now suggest that cells may spatially restrict oxidant production to allow microdomain-specific signaling.
Although reactive oxidants have long been stigmatized as unwanted metabolic byproducts, the expression of oxidases specifically functioning to produce these same molecules in a regulated fashion is surprisingly pervasive throughout metazoan and plant evolution. Although the involvement of oxidants in many signaling pathways is well documented, the cellular strategies for conferring pathway specificity to such reactive molecules have remained more recondite. Recent studies now suggest that cells may spatially restrict oxidant production to allow microdomain-specific signaling.