Association of Maternal-Neonatal Steroids With Early Pregnancy Endocrine Disrupting Chemicals and Pregnancy Outcomes
Association of Maternal-Neonatal Steroids With Early Pregnancy Endocrine Disrupting Chemicals and Pregnancy Outcomes
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DOI：
10.1210/clinem/dgaa909
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发表时间：
2021-03-08
影响因子：
5.8
通讯作者：
Padmanabhan, Vasantha
中科院分区：
文献类型：
--
作者：
Banker, Margaret;Puttabyatappa, Muraly;Padmanabhan, Vasantha
背景：类固醇在胎儿发育和分娩中起重要作用。妊娠期暴露于内分泌干扰化学物质（EDCs）会影响类固醇环境和妊娠结局，增加了类固醇作为生物标志物的可能性。大多数研究都没有解决EDC混合物的影响，这反映了现实生活中的情况。目的：评估孕产妇和新生儿类固醇与妊娠结局和妊娠早期EDC水平的关系。设计：对母子二人组进行前瞻性分析。单位：大学医院。参与者：121对母婴。主要结局指标：确定了121对母亲和新生儿类固醇激素与妊娠结局的关系，56对母亲和新生儿的孕早期EDCs单独和混合的关系，以及体重指数（BMI）、年龄和后代性别在调节EDC与类固醇的关系中的影响。结果：类固醇特异性阳性或阴性与妊娠措施明显相关；许多孕妇妊娠早期EDCs与雌激素呈负相关，与雄激素/雌激素比值呈正相关；edc -类固醇相关性受母亲年龄、孕前BMI和胎儿性别的影响；EDCs单独和混合与母体和新生儿类固醇呈直接和反向的胎儿性别依赖关系。结论：这项概念验证研究表明，类固醇与妊娠结局的关联取决于母亲年龄、孕前BMI和胎儿性别，而EDCs的作用在单独考虑或混合考虑时是不同的。这些发现表明，甾体激素测量有可能作为EDC暴露和妊娠结局影响的生物标志物。
Context: Steroids play an important role in fetal development and parturition. Gestational exposures to endocrine-disrupting chemicals (EDCs) affect steroidal milieu and pregnancy outcomes, raising the possibility of steroids serving as biomarkers. Most studies have not addressed the impact of EDC mixtures, which are reflective of real life scenarios.Objective: Assess the association of maternal and neonatal steroids with pregnancy outcomes and early pregnancy EDC levels.Design: Prospective analysis of mother-infant dyads.Setting: University hospital.Participants: 121 mother-infant dyads.Main Outcome Measures: The associations of maternal and neonatal steroidal hormones from 121 dyads with pregnancy outcomes, the associations of first trimester EDCs individually and as mixtures with maternal and neonatal steroids in a subset of 56 dyads and the influence of body mass index (BMI), age, and offspring sex in modulating the EDC associations with steroids were determined.Results: Steroid-specific positive or negative associations with pregnancy measures were evident; many maternal first trimester EDCs were negatively associated with estrogens and positively with androgen/estrogen ratios; EDC-steroid associations were influenced by maternal age, pre-pregnancy BMI, and fetal sex; and EDCs individually and as mixtures showed direct and inverse fetal sex-dependent associations with maternal and neonatal steroids.Conclusions: This proof-of-concept study indicates association of steroids with pregnancy outcomes depending on maternal age, prepregnancy BMI, and fetal sex, with the effects of EDCs differing when considered individually or as mixtures. These findings suggest that steroidal hormonal measures have potential to serve as biomarkers of impact of EDC exposures and pregnancy outcome.