Modulation of atopy patch test reactions by topical treatment of human skin with a fatty acid-rich emollient
Modulation of atopy patch test reactions by topical treatment of human skin with a fatty acid-rich emollient
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DOI：
10.1159/000049396
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发表时间：
2002-03-01
期刊：
影响因子：
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通讯作者：
Krutmann, J
中科院分区：
文献类型：
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作者：
Billmann-Eberwein, C;Rippke, F;Krutmann, J
旨在改善皮肤屏障功能的措施被认为在预防特应性皮炎复发方面有效，但润肤剂预防作用的直接证据一直难以捉摸。在目前的研究中，特应性斑贴试验被用作特应性皮炎的起始阶段的模型，以评估用富含脂肪酸的润肤剂(Eucerin(R)Omega Creme)对非皮损皮肤进行预处理是否对特应性皮炎患者具有预防作用。与相同患者(n=38)未经治疗的对照测试部位相比，用优赛林(注册商标)欧米茄乳膏对测试部位进行预处理可防止或减少湿疹的发展。这些研究表明，使用富含脂肪酸的润肤剂可以防止特应性湿疹的发展。他们还证明，特应性斑贴试验可以用来评估特定方案在这种疾病中发挥预防作用的能力。版权所有(C)2002 S.Karger AG，巴塞尔。
Measures directed at improving the skin barrier function are thought to be effective in preventing reexacerbation of atopic dermatitis, but direct proof of a prophylactic effect of emollients has been elusive. In the present study, the atopy patch test has been employed as a model for the initiation phase of atopic dermatitis in order to assess whether pretreatment of non-lesional skin with a fatty acid-rich emollient (Eucerin(R) Omega Creme) has a prophylactic effect in patients with atopic dermatitis. Pretreatment of test sites with Eucerin(R) Omega Creme either prevented or diminished the development of eczema, as compared with untreated control test sites in the same patients (n = 38). These studies indicate that the use of fatty acid-rich emollients prevents the development of atopic eczema. They also demonstrate that the atopy patch test can be used to assess the capacity of a given regimen to exert prophylactic effects in this disease. Copyright (C) 2002 S. Karger AG, Basel.