Selective lesion of septal cholinergic neurons in rats impairs acquisition of a delayed matching to position T-maze task by delaying the shift from a response to a place strategy
Selective lesion of septal cholinergic neurons in rats impairs acquisition of a delayed matching to position T-maze task by delaying the shift from a response to a place strategy
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DOI：
10.1016/j.brainresbull.2008.08.016
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发表时间：
2008-12-16
影响因子：
3.8
通讯作者：
Johnson, David A.
中科院分区：
文献类型：
--
作者：
Fitz, Nicholas F.;Gibbs, Robert B.;Johnson, David A.
本研究验证了中隔胆碱能损伤通过影响学习策略损害雄性大鼠延迟位置匹配（DMP） t迷宫任务习得的假设。将选择性胆碱能免疫毒素、192 igg皂苷（SAP）或人工脑脊液直接注入大鼠内侧隔膜。两周后，研究人员训练动物完成DMP任务。与对照组相比，接受sap治疗的大鼠获得任务所需的时间明显更长。在早期训练中，sap处理的大鼠和对照大鼠均采用持续转向和反应策略。当大鼠达到标准时，持续的转向不再明显，所有的大鼠都转向了一种非中心策略，即在很大程度上依赖于额外的线索。在获取期间，与相应的对照组相比，接受sap治疗的大鼠表现出持续转向和使用反应策略的时间明显更长。在接受sap治疗的大鼠中，使用反应策略所花费的额外时间完全占到了达到标准所需的额外天数。这表明，隔膜胆碱能损伤损害雄性大鼠DMP获得的主要机制是通过增加使用反应策略和位置策略的倾向，从而影响从一种策略转换到另一种策略的能力。(C) 2008爱思唯尔公司版权所有。
This study tested the hypothesis that septal cholinergic lesions impair acquisition of a delayed matching to position (DMP) T-maze task in male rats by affecting learning strategy. Rats received either the selective cholinergic immunotoxin, 192 IgG-saporin (SAP) or artificial cerebrospinal fluid directly into the medial septum. Two weeks later, animals were trained to acquire the DMP task. SAP-treated rats took significantly longer to acquire the task than corresponding controls. Both SAP-treated and control rats adopted a persistent turn and utilized a response strategy during early periods of training. By the time rats reached criterion the persistent turn was no longer evident, and all rats had shifted to an allocentric strategy, i.e., were relying on extramaze cues to a significant degree. During the acquisition period, SAP-treated rats spent significantly more days showing a persistent turn and using a response strategy than corresponding controls. The added time spent using a response strategy accounted entirely for the added days required to reach criterion among the SAP-treated rats. This suggests that the principal mechanism by which septal cholinergic lesions impair DMP acquisition in male rats is by increasing the predisposition to use a response vs. a place strategy, thereby affecting the ability to switch from one strategy to another. (C) 2008 Elsevier Inc. All rights reserved.