Recurrence-free survival in breast cancer is associated with MRI tumor enhancement dynamics quantified using computer algorithms
Recurrence-free survival in breast cancer is associated with MRI tumor enhancement dynamics quantified using computer algorithms
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DOI：
10.1016/j.ejrad.2015.07.012
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发表时间：
2015-11-01
影响因子：
3.3
通讯作者：
Johnson, Karen S.
中科院分区：
文献类型：
--
作者：
Mazurowski, Maciej A.;Grimm, Lars J.;Johnson, Karen S.
目的：本研究的目的是探讨乳腺癌复发无瘤生存和乳腺磁共振成像（MRI）肿瘤增强动力学的半自动量化使用computeralgorithm.Methods：在这个回顾性IRB批准的研究，我们分析了275例乳腺癌患者在一个单一的机构的数据之间的关联。无复发生存数据来自病历。对所有患者进行常规临床术前乳腺MRI检查。肿瘤由接受过研究员培训的乳腺放射科医生在MRI上标记。先前开发的计算机算法应用于标记的肿瘤，以量化相对于自动评估的背景实质增强的增强动力学。为了确定算法量化的对比度增强特征是否与无复发生存期相关，我们构建了一个考克斯比例风险回归模型，以计算机提取的特征作为协变量。我们控制了肿瘤的等级和大小结果：分析显示，半自动获得的量化MRI肿瘤增强动力学的特征独立预测无复发生存率。（p = 0.024）。MRI上半自动量化的肿瘤增强动力学可预测乳腺癌患者的无复发生存期。(C)2015爱思唯尔爱尔兰有限公司版权所有。
Purpose: The purpose of this study is to investigate the association between breast cancer recurrencefree survival and breast magnetic resonance imaging (MRI) tumor enhancement dynamics which are quantified semi-automatically using computer algorithms.Methods: In this retrospective IRB-approved study, we analyzed data from 275 breast cancer patients at a single institution. Recurrence-free survival data were obtained from the medical record. Routine clinical pre-operative breast MRIs were performed in all patients. The tumors were marked on the MRIs by fellowship-trained breast radiologists. A previously developed computer algorithm was applied to the marked tumors to quantify the enhancement dynamics relative to the automatically assessed background parenchymal enhancement. To establish whether the contrast enhancement feature quantified by the algorithm was associated with recurrence-free survival, we constructed a Cox proportional hazards regression model with the computer-extracted feature as a covariate. We controlled for tumor grade and size (major axis length), patient age, patient race/ethnicity, and menopausal status.Results: The analysis showed that the semi-automatically obtained feature quantifying MRI tumor enhancement dynamics was independently predictive of recurrence-free survival (p = 0.024).Conclusion: Semi-automatically quantified tumor enhancement dynamics on MRI are predictive of recurrence-free survival in breast cancer patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.