Neuronal effects of neurokinin B on the rat subfornical organ
Neuronal effects of neurokinin B on the rat subfornical organ
复制标题
神经激肽B对大鼠穹窿下器官的神经元作用
DOI：
10.1097/wnr.0b013e3283469645
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发表时间：
2011
期刊：
影响因子：
1.7
通讯作者：
Inenaga K.
中科院分区：
文献类型：
--
作者：
Ono K;Asami R;Miyahara N;Nakanishi O;Inenaga K.
穹窿下器是血管紧张素II诱导体液调节的重要中枢核团。与血管紧张素II相似，中枢注射神经激肽B（NKB）可通过穹窿下器官诱导心血管反应;然而，它不诱导水摄入。为了澄清这种不一致性，我们研究了NKB对穹窿下器官神经元的神经元效应沿着在体内的行为效应。在电生理细胞外记录中，NKB兴奋血管紧张素II不敏感的神经元并抑制血管紧张素II敏感的神经元。中心注射NKB抑制外周注射血管紧张素II诱导的水摄入。这些结果表明，NKB介导的神经元对穹窿下器官的影响，可能参与antidipsogenic反应，除了以前报道的心血管反应。
The subfornical organ is an essential central nucleus for angiotensin II-induced body fluid regulation. Similar to angiotensin II, centrally injected neurokinin B (NKB) may induce cardiovascular responses by the subfornical organ; however, it does not induce water intake. To clarify this inconsistency, we investigated the neuronal effects of NKB on subfornical organ neurons in slice preparations along with its behavioral effects in vivo. In electrophysiological extracellular recordings, NKB excited angiotensin II-insensitive and inhibited angiotensin II-sensitive neurons. Centrally injected NKB inhibited peripherally injected angiotensin II-induced water intake. These results suggest that NKB-mediated neuronal effects on the subfornical organ are likely to be involved in antidipsogenic responses in addition to the previously reported cardiovascular responses.