"New"-clear functions of PDK1: Beyond a master kinase in the cytosol?
"New"-clear functions of PDK1: Beyond a master kinase in the cytosol?
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DOI：
10.1002/jcb.20651
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发表时间：
2005-12-15
影响因子：
4
通讯作者：
Liu, F
中科院分区：
文献类型：
--
作者：
Kikani, CK;Dong, LQ;Liu, F
胞浆磷脂酰肌醇-3激酶（PI-3 K）信号通路的激活已经被很好地建立，以调节基因表达，细胞周期，并通过向细胞核馈送信号来调节存活。此外，过去几年积累的强有力证据表明，细胞核内存在自主的肌醇脂质代谢和PI-3 K信号转导。然而，对这种核PI-3 K通路的作用和调节知之甚少。PI-3 K信号通路的组分，包括PI 3-激酶及其下游激酶Akt，已经在核水平上被鉴定。与。由于细胞核中存在完整的PI-3 K信号通路，我们最近发现磷酸肌醇依赖性激酶1（PDK 1），一种在PI-3 K下游和Akt上游起作用的激酶，是一种核质穿梭蛋白。本文就PDK 1核转位的调控机制和功能作用作一综述。我们还总结了一些激酶独立的活动PDK 1在细胞信号。J.细胞。96：1157-1162，2005. (c)2005 Wiley-Liss，Inc.
Activation of cytosolic phosphoinositide-3 kinase (PI-3K) signaling pathway has been well established to regulate gene expression, cell cycle, and survival by feeding signals to the nucleus. In addition, strong evidences accumulated over the past few years indicate the presence of an autonomous inositol lipid metabolism and PI-3K signaling within the nucleus. Much less, however, is known about the role and regulation of this nuclear PI-3K pathway. Components of the PI-3K signaling pathway, including PI 3-kinase and its downstream kinase Akt, have been identified at the nuclear level. Consistent with the. presence of a complete PI-3K signaling pathway in the nucleus, we have recently found that phosphoinositide-dependent kinase 1 (PDK1), a kinase functioning downstream of PI-3K and upstream of Akt, is a nucleo-cytoplasmic shuttling protein. In the present review, we update our current knowledge on the regulatory mechanisms and the functional roles of PDK1 nuclear translocation. We also summarize some of the kinase-independent activities of PDK1 in cell signaling. J. Cell. Biochem. 96: 1157-1162, 2005. (c) 2005 Wiley-Liss, Inc.