Sestrin regulates acute chill coma recovery in Drosophila melanogaster.
Sestrin regulates acute chill coma recovery in Drosophila melanogaster.
复制标题
Sestrin调节了果蝇Melanogaster中的急性寒冷康复。
DOI：
10.1016/j.ibmb.2021.103548
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发表时间：
2021-06
影响因子：
3.8
通讯作者：
Wessells R
中科院分区：
文献类型：
--
作者：
Cobb T;Damschroder D;Wessells R
When chill-susceptible insects are exposed to low temperatures they enter a temporary state of paralysis referred to as a chill coma. The most well-studied physiological mechanism of chill coma onset and recovery involves regulation of ion homeostasis. Previous studies show that changes in metabolism may also underlie the ability to recovery quickly, but the roles of genes that regulate metabolic homeostasis in chill coma recovery time (CCRT) are not well understood. Here, we investigate the roles of Sestrin and Spargel (Drosophila homolog of PGC-1α), which are involved in metabolic homeostasis and substrate oxidation, on CCRT in Drosophila melanogaster. We find that sestrin and spargel mutants have impaired CCRT. sestrin is required in the muscle and nervous system tissue for normal CCRT and spargel is required in muscle and adipose. On the basis that exercise induces sestrin and spargel, we also test the interaction of cold and exercise. We find that pre-treatment with one of these stressors does not consistently confer acute protection against the other. We conclude that Sestrin and Spargel are important in the chill coma response, independent of their role in exercise.
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影响因子：
4
作者：
Enriquez, Thomas;Renault, David;Colinet, Herve
通讯作者：
Colinet, Herve
DOI：
10.1002/jez.2253
发表时间：
2019-03-01
影响因子：
2.8
作者：
Garcia, Mark J.;Teets, Nicholas M.
通讯作者：
Teets, Nicholas M.
影响因子：
8.1
作者：
Heinrichsen ET;Zhang H;Robinson JE;Ngo J;Diop S;Bodmer R;Joiner WJ;Metallo CM;Haddad GG
通讯作者：
Haddad GG
影响因子：
56.9
作者：
LEE, RE;CHEN, CP;DENLINGER, DL
通讯作者：
DENLINGER, DL
影响因子：
16.6
作者：
Kim, Myungjin;Sujkowski, Alyson;Lee, Jun Hee
通讯作者：
Lee, Jun Hee