Titanium dioxide nanoparticles relieve biochemical dysfunctions of fifth-instar larvae of silkworms following exposure to phoxim insecticide
Titanium dioxide nanoparticles relieve biochemical dysfunctions of fifth-instar larvae of silkworms following exposure to phoxim insecticide
复制标题
二氧化钛纳米颗粒可缓解接触辛硫磷杀虫剂后蚕五龄幼虫的生化功能障碍
DOI：
10.1016/j.chemosphere.2012.05.061
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发表时间：
2012-10-01
期刊：
影响因子：
8.8
通讯作者：
Hong, Fashui
中科院分区：
文献类型：
--
作者：
Li, Bing;Hu, Rengping;Hong, Fashui
辛硫磷是一种广泛应用于农业生产的杀虫剂，对害虫和非靶标生物具有一定的毒性。辛硫磷中毒对家蚕来说是难以预防的。二氧化钛纳米粒子已被广泛应用于增白、增亮食品、牙膏或防晒剂以及口服药物。然而，纳米TiO2是否能提高家蚕对辛硫磷的抗性尚未见报道。结果表明，添加纳米TiO2颗粒显著降低了辛硫磷暴露引起的家蚕血淋巴蛋白质、葡萄糖、丙酮酸含量、乳酸脱氢酶、琥珀酸脱氢酶和苹果酸脱氢酶活性的下降，并缓解了游离氨基酸、尿素、尿酸、乳酸水平、蛋白酶、丙氨酸氨基转移酶和天冬氨酸氨基转移酶活性的升高。从本研究中可以清楚地看出，添加TiO2纳米颗粒可以减轻辛硫磷杀虫剂对家蚕代谢的毒性影响，这反过来又可以导致产丝量的增加。皇冠版权所有（C）2012由爱思唯尔有限公司出版。保留所有权利。
Phoxim insecticide is widely used in agriculture, which is toxic to insect pests and nontarget organisms. The phoxim poisoning is hard to prevent for silkworms. TiO2 NPs have been widely applied in whitening, brightening foods, toothpaste or sunscreens, and orally-administered drugs. However, whether TiO2 NPs can increase resistance of silkworm to phoxim poisoning has not been reported. The results demonstrated that added TiO2 NPs significantly decreased reduction of protein, glucose and pyruvate contents, lactate dehydrogenase, succinate dehydrogenase and malate dehydrogenase activities, and attenuated increases of free amino acids, urea, uric acid and lactate levels, activities of protease, alanine aminotransferase and aspartate aminotransferase in the hemolymph of silkworms caused by phoxim exposure. From the present study, it is clearly evident that added TiO2 NPs may relieve toxic impacts of phoxim insecticide on silkworm metabolism, which in turn may result in an increase in silk yield. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.