PROGRESSION OF PERIODONTAL-DISEASE IN HIV-SEROPOSITIVE PATIENTS
PROGRESSION OF PERIODONTAL-DISEASE IN HIV-SEROPOSITIVE PATIENTS
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DOI：
10.1902/jop.1993.64.7.651
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发表时间：
1993-07-01
影响因子：
4.3
通讯作者：
SINDHUSAKE, D
中科院分区：
文献类型：
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作者：
YEUNG, SCH;STEWART, GJ;SINDHUSAKE, D
横断面研究的数据表明，HIV感染患者的牙周炎是一种更具破坏性的疾病，与一般人群中进展缓慢的成人牙周炎相比。我们前瞻性研究了30例HIV感染但无症状的患者，并将其牙周附着丧失率与年龄和菌斑指数匹配的健康对照组（n = 10）进行了比较。每6个月，由医生评估每例受试者的临床状态和CD4+细胞计数。测定用PHA和ConA体外培养法测定外周血淋巴细胞的增殖反应。采用菌斑指数（PI）、牙龈指数（GI）、牙周病指数（PDI）对牙周健康状况进行评分。对照组仅评估牙周状况。在30名艾滋病毒阳性患者的数据进行了分析，14人接受齐多夫定（AZT），而其余16人没有。任何临床参数测量和牙周状况之间没有相关性，由PI或GI确定。而牙周病指数（PDI）的变化在HIV感染组和对照组之间有显著性差异（P = 0.005）。我们的结论是，与对照组相比，HIV感染的牙周炎患者随着时间的推移往往会经历更大的附着丧失率。
DATA FROM CROSS-SECTIONAL STUDIES suggest that periodontitis in HIV-infected patients is a more destructive form of disease in contrast to the slowly progressing form of adult periodontitis in the general population. We studied prospectively over an 18-month period 30 HIV infected, but asymptomatic, patients and compared the rate of periodontal attachment loss with that of a healthy control group (n = 10) matched for age and plaque index. Every 6 months, each subject was assessed for their clinical status by a physician and CD4+ cell count. determined. The proliferative response of peripheral blood lymphocytes was determined by in vitro cultures with PHA and Con A. The periodontal health status was assessed by scoring with plaque index (PI), gingival index (GI), and periodontal disease index (PDI). The control subjects were assessed for periodontal status only. Of the 30 HIV-positive patients whose data were analyzed 14 received Zidovudine (AZT) while the remaining 16 did not. There was no correlation between any clinical parameter measured and periodontal status as determined by PI or GI. However, a significant difference in the change of periodontal disease index (PDI) was observed between the HIV-infected and control groups (P = 0.005). We concluded that HIV-infected patients with pre-existing periodontitis tend to experience a greater rate of attachment loss over time compared with controls.