miR-210: More than a silent player in hypoxia.
miR-210: More than a silent player in hypoxia.
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多项研究一致证实，miR (microRNA)-210 诱导是正常细胞和转化细胞缺氧反应的一个特征。在这里，我们讨论该 miRNA 的新兴生化功能并预测潜在的临床应用。 miR-210是缺氧诱导因子的有力靶标，其过度表达已在多种心血管疾病和实体瘤中检测到。高水平的 miR-210 与体内缺氧特征有关，并与癌症患者的不良预后相关。广泛的 miR-210 靶点已被确定，在线粒体代谢、血管生成、DNA 修复和细胞存活中发挥作用。这些目标可能广泛影响肿瘤和其他病理环境（例如缺血性疾病）的演变。利用 miR-210 作用的知识可能会带来新的诊断和治疗方法。
Multiple studies have consistently established that miR (microRNA)-210 induction is a feature of the hypoxic response in both normal and transformed cells. Here, we discuss the emerging biochemical functions of this miRNA and anticipate potential clinical applications. miR-210 is a robust target of hypoxia-inducible factor, and its overexpression has been detected in a variety of cardiovascular diseases and solid tumors. High levels of miR-210 have been linked to an in vivo hypoxic signature and associated with adverse prognosis in cancer patients. A wide spectrum of miR-210 targets have been identified, with roles in mitochondrial metabolism, angiogenesis, DNA repair, and cell survival. Such targets may broadly affect the evolution of tumors and other pathological settings, such as ischemic disorders. Harnessing the knowledge of miR-210’s actions may lead to novel diagnostic and therapeutic approaches.
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影响因子：
2.7
作者：
Guimbellot JS;Erickson SW;Mehta T;Wen H;Page GP;Sorscher EJ;Hong JS
通讯作者：
Hong JS
影响因子：
3.7
作者：
Favaro E;Ramachandran A;McCormick R;Gee H;Blancher C;Crosby M;Devlin C;Blick C;Buffa F;Li JL;Vojnovic B;Pires das Neves R;Glazer P;Iborra F;Ivan M;Ragoussis J;Harris AL
通讯作者：
Harris AL
影响因子：
37.8
作者：
Hu S;Huang M;Li Z;Jia F;Ghosh Z;Lijkwan MA;Fasanaro P;Sun N;Wang X;Martelli F;Robbins RC;Wu JC
通讯作者：
Wu JC
影响因子：
2.1
作者：
Juan, David;Alexe, Gabriela;Liou, Louis S.
通讯作者：
Liou, Louis S.
影响因子：
5.3
作者：
Bindra, RS;Schaffer, PJ;Glazer, PM
通讯作者：
Glazer, PM