Engineering target-responsive hydrogels based on aptamer - Target interactions
Engineering target-responsive hydrogels based on aptamer - Target interactions
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DOI：
10.1021/ja801339w
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发表时间：
2008-05-21
影响因子：
15
通讯作者：
Tan, Weihong
中科院分区：
文献类型：
--
作者：
Yang, Huanghao;Liu, Haipeng;Tan, Weihong
在这次交流中，我们报告了一个简单的，但适应性强，使用DNA适体构建选择性靶向响应水凝胶的方法。通过使用线性聚合物链作为水凝胶骨架和DNA适体作为交联剂来实现设计的简单性。在这种设计中，靶与适体的竞争性结合导致交联密度的降低，从而导致水凝胶的溶解。使用两种不同类型的靶标（小分子和蛋白质）证明了这种策略对治疗应用的适应性。我们的结果表明，这种分子工程提供了一种高度选择性和可控的释放系统，从而可以在发现靶生物标志物的特定环境中有效释放治疗剂。
In this communication, we report a simple, but highly adaptable, method of constructing selective target-responsive hydrogels using DNA aptamers. The simplicity of the design is accomplished by using linear polymer chains as the hydrogel backbone and a DNA aptamer as the cross-linker. in this design, competitive binding of target to the aptamer causes the decrease of cross-linking density and, hence, dissolution of the hydrogel. The adaptability of this strategy for therapeutic applications was demonstrated using two different types of targets, small molecules and proteins. Our results indicated that this molecular engineering provides a highly selective and controllable release system whereby efficient release of therapeutic agents can occur at specific environments in which the target biomarker is found.