Asymptomatic and neurologically symptomatic HIV-seropositive individuals: prospective evaluation with cranial MR imaging.
Asymptomatic and neurologically symptomatic HIV-seropositive individuals: prospective evaluation with cranial MR imaging.
复制标题
无症状和有神经症状的 HIV 血清阳性个体：颅脑 MR 成像的前瞻性评估。
DOI：
10.1148/radiology.178.1.1984291
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发表时间：
1991
期刊：
影响因子：
19.7
通讯作者：
Quencer,RM
中科院分区：
文献类型：
--
作者：
Post,MJ;Berger,JR;Quencer,RM
作为对人类免疫缺陷病毒（HIV）血清阳性个体的前瞻性多学科研究的一部分，对119例HIV血清阳性受试者（95例无症状，24例有症状）进行了头颅磁共振（MR）成像，并将结果与临床数据相关联。认为阳性的MR图像包括显示萎缩和/或白色病变的图像。根据这些标准，96名受试者的MR图像正常，23名受试者的图像异常。卡方分析结果显示无症状组（95例中有12例[13%]扫描异常）和有症状组（24例中有11例[46%]扫描异常）之间存在统计学显著差异（P = 0.001）。在无症状组中，阳性MR图像显示较少、较小和/或不太广泛的异常。研究人员得出的结论是：（a）MR成像可以显示疾病早期HIV感染的间接证据，但异常很小，仅在少数神经系统无症状受试者中可见;（B）临床可识别的神经系统疾病的出现与越来越严重的脑萎缩和白色物质病变的MR成像结果相关;和（c）在一些HIV血清阳性受试者中，尽管有神经系统疾病，MR图像可以保持正常。结果表明，常规筛查与颅脑磁共振成像的神经系统无症状的艾滋病毒血清阳性个体可能会导致低产量的阳性结果。
As part of a prospective multidisciplinary study of individuals seropositive for the human immunodeficiency virus (HIV), cranial magnetic resonance (MR) imaging was performed on 119 HIV-seropositive subjects (95 asymptomatic, 24 symptomatic) and the results were correlated with clinical data. MR images regarded as positive included those showing atrophy and/or white matter lesions. On the basis of these criteria, 96 subjects had normal MR images and 23 had abnormal images. Results of chi 2 analysis revealed a statistically significant difference between the asymptomatic group (12 of 95 [13%] with abnormal scans) and the symptomatic group (11 of 24 [46%] with abnormal scans) (P = .001). In the asymptomatic group, positive MR images showed fewer, smaller, and/or less extensive abnormalities. The researchers conclude that (a) MR imaging can show indirect evidence of HIV infection early in the disease, but abnormalities will be minor and seen only in a small minority of neurologically asymptomatic subjects; (b) the appearance of clinically recognizable neurologic disease correlates with the MR imaging findings of increasingly severe brain atrophy and white matter lesions; and (c) in some HIV-seropositive subjects, despite neurologic disease, MR images can remain normal. Results indicate that routine screening with cranial MR imaging of neurologically asymptomatic HIV-seropositive individuals would likely result in a low yield of positive findings.