AXONAL PROJECTIONS FROM THE ROSTRAL EXPIRATORY NEURONS OF THE BOTZINGER COMPLEX TO MEDULLA AND SPINAL-CORD IN THE CAT
AXONAL PROJECTIONS FROM THE ROSTRAL EXPIRATORY NEURONS OF THE BOTZINGER COMPLEX TO MEDULLA AND SPINAL-CORD IN THE CAT
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DOI：
10.1113/jphysiol.1984.sp015214
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发表时间：
1984-01-01
影响因子：
5.5
通讯作者：
MERRILL, EG
中科院分区：
文献类型：
--
作者：
FEDORKO, L;MERRILL, EG
在麻醉猫的情况下，用反交点映射技术测试了84个吻侧髓质呼气神经元的轴突投影。12个被测神经元中有11个显示向髓质的腹侧呼吸神经元（n.r.a.）的投射。在>中，72%的被测神经元可见到C[颈]5-C6颈椎节段的脊髓投影；可能接近100%的项目到颈髓。双侧脑干和脊髓均可见轴突突起。大多数Boetzinger复合体呼气神经元具有2-4个轴突侧支，连接孤立束腹外侧核和/或脊髓。在测试的12个神经元中，有8个神经元在吸气区、呼气区和中枢性颞叶颞叶区均有轴突树突的电生理证据。在膈运动核中26%的被测神经元中发现了类似的终末树突的证据。Boetzinger复合体神经元的下行脊髓呼气轴突位于C4和C5节段的外侧索背和内侧。传导速度测量表明这些是大的髓鞘轴突。Boetzinger复合体呼气神经元可能是nra、吸气神经元和膈运动神经元突触抑制的一个来源。
Axonal projections of 84 rostral medullary expiratory neurons of the Boetzinger complex were tested using antidromic mapping techniques in anesthetized cats. A projection to the ventral respiratory neurons of the medulla (n.r.a.) was shown in 11 of 12 tested neurons. Also a spinal projection to the C[cervical]5-C6 cervical segments was evident in > 72% of tested neurons; probably near 100% project to cervical cord. These axonal projections were found bilaterally in both brain stem and spinal cord. The majority of Boetzinger complex expiratory neurons had 2-4 axonal collaterals to the ventrolateral (v.l.) nucleus of the solitary tract (n.t.s.) and/or the n.r.a. and/or the spinal cord. In 8 of 12 of the tested neurons, electrophysiological evidence of axonal arborization in > 1 of n.r.a. inspiratory, n.r.a. expiratory or v.l. n.t.s. regions was obtained. Similar evidence for the terminal arborization was found for 26% of tested neurons in the phrenic motor nucleus. The descending spinal expiratory axons of the Boetzinger complex neurons are located in the dorsal and medial parts of the lateral funiculus in C4 and C5 segments. Conduction velocity measurements indicate that these are large myelinated axons. The Boetzinger complex expiratory neurons may be a source of synaptic inhibition for n.r.a. inspiratory neurons and phrenic motoneurons.