PLASMA-CELLS PRODUCING LAMBDA-LIGHT CHAINS ARE PREDOMINANT IN HUMAN GUT AND TONSILS - AN IMMUNOHISTOMORPHOMETRIC STUDY
PLASMA-CELLS PRODUCING LAMBDA-LIGHT CHAINS ARE PREDOMINANT IN HUMAN GUT AND TONSILS - AN IMMUNOHISTOMORPHOMETRIC STUDY
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DOI：
10.1093/ajcp/94.5.571
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发表时间：
1990-11-01
影响因子：
3.5
通讯作者：
BENE, MC
中科院分区：
文献类型：
--
作者：
FAURE, GC;TANG, JG;BENE, MC
对十二指肠（10）和扁桃体（25）的人体样本进行了免疫组织形态学研究，以评估产生κ或λ链的浆细胞数量。使用不同的试剂并仔细测定特异性和交叉反应性的存在。在用作试剂对照样品的46个骨髓来源的B细胞增殖中，主要发现这些抗体的κ链。相比之下，在粘膜组织样品中发现产生λ链的浆细胞更多。观察到的κ/λ比为0.53。这一发现可能是反映人类粘膜免疫系统（MALT）自主性的另一个特征。
An immunohistomorphometric study was performed on human samples of duodenum (10) and tonsil (25) to assess the numbers of plasma cells producing kappa or lambda chains. Different reagents were used and carefully assayed for specificity and absence of cross-reactivity. Kappa chains were found predominantly with these antibodies in 46 bone marrow-derived B-cell proliferations used as reagents'' control samples. In contrast, plasma cells producing lambda chains were found to be more numerous in the samples of mucosal tissues. The kappa/lambda ratio observed was 0.53. This finding could be another feature reflecting the autonomy of the immune system of mucosae (MALT) in humans.