Height, adiposity and body fat distribution and breast density in young women
Height, adiposity and body fat distribution and breast density in young women
复制标题
DOI：
10.1186/bcr3228
复制
发表时间：
2012-01-01
影响因子：
7.4
通讯作者：
Hylton, Nola M.
中科院分区：
文献类型：
--
作者：
Dorgan, Joanne F.;Klifa, Catherine;Hylton, Nola M.
简介：乳腺密度是乳腺癌的最强的危险因素之一，但乳腺密度在年轻women.Methods的决定因素仍然在很大程度上unknown：协会的身高，肥胖和体脂分布与致密乳腺体积百分比（%DBV）和绝对致密乳腺体积（ADBV）进行了评估，在一项横断面研究的174名健康女性，25至29岁。通过人体测量法和双能X线吸收法（DXA）测量肥胖和体脂分布，而通过磁共振成像测量%DBV和ADBV。使用线性混合效应模型评估相关性。结果：身高与%DBV显著正相关，但与ADBV无关;身高每增加一个标准差（SD），校正模型中%DBV增加18.7%。相反，所有肥胖和体脂分布指标均与%DBV显著负相关;校正儿童BMI和其他协变量后，体重指数（BMI）、脂肪质量百分比、腰围和男性：女性脂肪质量比（A：G比）的SD增加均与%DBV下降44.4%至47.0%显著相关。虽然与%DBV的相关性较弱，但在校正儿童BMI之前，所有肥胖和体脂分布指标与ADBV均呈显著负相关。然而，在校正儿童BMI后，只有脂肪质量百分比和A：G比率的DXA测量值仍然显著;每个SD增加与ADBV降低13.8%至19.6%相关。在相互校正分析中，脂肪质量百分比和A：G比率与%DBV显著负相关，但只有A：G比率与ADBV显著相关; A：G比率的SD增加与ADBV降低18.5%相关。总肥胖和体脂分布与%DBV独立负相关，而在相互校正分析中，（答：G比率）与年轻女性的ADBV呈显著负相关。需要进行研究以确定这些关联背后的生物学机制。
Introduction: Breast density is one of the strongest risk factors for breast cancer, but determinants of breast density in young women remain largely unknown.Methods: Associations of height, adiposity and body fat distribution with percentage dense breast volume (%DBV) and absolute dense breast volume (ADBV) were evaluated in a cross-sectional study of 174 healthy women, 25 to 29 years old. Adiposity and body fat distribution were measured by anthropometry and dual-energy X-ray absorptiometry (DXA), while %DBV and ADBV were measured by magnetic resonance imaging. Associations were evaluated using linear mixed-effects models. All tests of statistical significance are two-sided.Results: Height was significantly positively associated with %DBV but not ADBV; for each standard deviation (SD) increase in height, %DBV increased by 18.7%in adjusted models. In contrast, all measures of adiposity and body fat distribution were significantly inversely associated with %DBV; a SD increase in body mass index (BMI), percentage fat mass, waist circumference and the android:gynoid fat mass ratio (A: G ratio) was each associated significantly with a 44.4 to 47.0% decrease in %DBV after adjustment for childhood BMI and other covariates. Although associations were weaker than for %DBV, all measures of adiposity and body fat distribution also were significantly inversely associated with ADBV before adjustment for childhood BMI. After adjustment for childhood BMI, however, only the DXA measures of percentage fat mass and A: G ratio remained significant; a SD increase in each was associated with a 13.8 to 19.6% decrease in ADBV. In mutually adjusted analysis, the percentage fat mass and the A: G ratio remained significantly inversely associated with %DBV, but only the A: G ratio was significantly associated with ADBV; a SD increase in the A: G ratio was associated with an 18.5% decrease in ADBV.Conclusion: Total adiposity and body fat distribution are independently inversely associated with %DBV, whereas in mutually adjusted analysis only body fat distribution (A: G ratio) remained significantly inversely associated with ADBV in young women. Research is needed to identify biological mechanisms underlying these associations.