Novel approaches to vaccine development against HBV.
Novel approaches to vaccine development against HBV.
复制标题
乙型肝炎疫苗开发的新方法。
DOI：
10.1016/0168-1656(95)00117-4
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Thanavala,Y
中科院分区：
文献类型：
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作者：
Thanavala,Y
这篇综述总结了我实验室基于两种新的方法对B型肝炎表面抗原疫苗开发的研究。第一种方法涉及单克隆抗独特型抗体在功能上模拟HBsAg α决定簇的能力。第二种方法利用基因工程植物的策略，使它们可以用作生产候选疫苗抗原的发酵系统的廉价替代品。
This review summarizes studies from my laboratory based on two novel approaches towards vaccine development against hepatitis B surface antigen. The first approach deals with the ability of a monoclonal anti-idiotypic antibody to functionally mimic the a determinant of HBsAg. The second approach exploits the strategy of genetically engineering plants so that they can be used as inexpensive alternatives to fermentation systems for the production of candidate vaccine antigens.