Assessing Cyanobacterial Harmful Algal Blooms as Risk Factors for Amyotrophic Lateral Sclerosis.
Assessing Cyanobacterial Harmful Algal Blooms as Risk Factors for Amyotrophic Lateral Sclerosis.
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DOI：
10.1007/s12640-017-9740-y
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发表时间：
2018-01
影响因子：
3.7
通讯作者：
Shi X
中科院分区：
文献类型：
--
作者：
Torbick N;Ziniti B;Stommel E;Linder E;Andrew A;Caller T;Haney J;Bradley W;Henegan PL;Shi X
在许多沃茨中，季节性蓝藻有害藻华（CHAB）的重复发生持续存在，最近的研究表明CHAB与肌萎缩侧索硬化症（ALS）风险升高之间存在联系。量化CHAB作为ALS潜在风险因素的暴露水平因人类流动性、潜在途径和数据可用性而变得复杂。在这项工作中，我们开发了藻蓝蛋白浓度（即，CHAB暴露）地图，使用卫星遥感横跨北方新英格兰，以评估与ALS病例的关系，使用空间流行病学方法。战略半分析回归模型集成了陆地卫星和原位观测地图藻蓝蛋白浓度（PC）的所有湖泊大于8公顷（n = 4117）整个地区。然后，系统版本的贝叶斯泊松对数线性模型进行拟合，以评估映射的PC作为ALS的风险因素，同时考虑模型的不确定性和可修改的面积单位问题。PC的卫星遥感有很强的整体能力，地图条件（调整R2，0.86; RMSE，11.92）和整个区域的空间变异性。PC倾向于与ALS风险正相关，其显著性水平取决于固定模型组件。荟萃分析显示，当平均PC暴露量为100 μg/L时，所有模型的平均比值比为1.48，这意味着平均ALS风险增加约48%。这项研究为数千个湖泊生成了第一个区域综合PC地图，并集成了强大的空间不确定性。这些结果支持了藻毒素增加ALS风险的假设，这有助于我们了解ALS的病因。
Reoccurring seasonal cyanobacterial harmful algal blooms (CHABs) persist in many waters, and recent work has shown links between CHAB and elevated risk of amyotrophic lateral sclerosis (ALS). Quantifying the exposure levels of CHAB as a potential risk factor for ALS is complicated by human mobility, potential pathways, and data availability. In this work, we develop phycocyanin concentration (i.e., CHAB exposure) maps using satellite remote sensing across northern New England to assess relationships with ALS cases using a spatial epidemiological approach. Strategic semi-analytical regression models integrated Landsat and in situ observations to map phycocyanin concentration (PC) for all lakes greater than 8 ha (n = 4117) across the region. Then, systematic versions of a Bayesian Poisson Log-linear model were fit to assess the mapped PC as a risk factor for ALS while accounting for model uncertainty and modifiable area unit problems. The satellite remote sensing of PC had strong overall ability to map conditions (adj. R2, 0.86; RMSE, 11.92) and spatial variability across the region. PC tended to be positively associated with ALS risk with the level of significance depending on fixed model components. Meta-analysis shows that when average PC exposure is 100 μg/L, an all model average odds ratio is 1.48, meaning there is about a 48% increase in average ALS risk. This research generated the first regionally comprehensive map of PC for thousands of lakes and integrated robust spatial uncertainty. The outcomes support the hypothesis that cyanotoxins increase the risk of ALS, which helps our understanding of the etiology of ALS.
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DOI：
10.1080/10618600.2014.948178
发表时间：
2015-09-16
期刊：
Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America
影响因子：
--
作者：
Hughes J
通讯作者：
Hughes J
DOI：
10.1098/rspb.2015.2397
发表时间：
2016-01-27
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Cox PA;Davis DA;Mash DC;Metcalf JS;Banack SA
通讯作者：
Banack SA
影响因子：
9.9
作者：
Cox, PA;Sacks, OW
通讯作者：
Sacks, OW
DOI：
10.1073/pnas.2235808100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Cox, PA;Banack, SA;Murch, SJ
通讯作者：
Murch, SJ
DOI：
10.1111/j.1467-9868.2012.01041.x
发表时间：
2013-01-01
影响因子：
5.8
作者：
Hughes, John;Haran, Murali
通讯作者：
Haran, Murali