Radiographic features of lumbar disc degeneration and bone mineral density in men and women
Radiographic features of lumbar disc degeneration and bone mineral density in men and women
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DOI：
10.1136/ard.2005.038224
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发表时间：
2006-02-01
影响因子：
27.4
通讯作者：
O'Neill, TW
中科院分区：
文献类型：
--
作者：
Pye, SR;Reid, DM;O'Neill, TW
目的：确定腰椎间盘退变的个体放射学特征与脊柱和髋部骨密度（BMD）之间的关系。方法：从登记的人群中招募受试者进行椎体骨质疏松症的筛查调查。采用双能x线骨密度仪评估脊柱和髋部骨密度。腰椎侧位x线片评估腰椎间盘退变的特征。评估从L1/2到L4/5的每个椎节是否存在骨赘、终板硬化和椎间盘间隙狭窄及其严重程度。使用线性回归来确定这些特征与脊柱和髋关节骨密度之间的关系，并对年龄、体重指数和身体活动水平进行调整。对男性和女性分别进行了分析。结果：250名女性和256名男性（平均年龄在65岁左右）被研究。在腰椎，年龄调整后，男女椎间盘退变的所有影像学特征的骨密度都随着分级的增加而增加。在股骨颈，经过年龄调整后，骨密度增加，骨疣和终板硬化程度增加，但椎间盘间隙没有缩小。调整体重指数和体力活动并不影响这种关联的强度。结论：腰椎间盘退变的影像学特征与脊柱骨密度增加有关。骨赘和终板硬化与髋部骨密度增加有关，但与椎间盘间隙狭窄无关。
Objectives: To determine the association between individual radiographic features of lumbar disc degeneration and bone mineral density (BMD) at the spine and hip.Methods: Subjects were recruited from a population register for a screening survey of vertebral osteoporosis. BMD was assessed at the spine and hip using dual energy x ray absorptiometry. Lateral spinal radiographs were evaluated for features of lumbar disc degeneration. Each vertebral level from L1/2 to L4/5 was assessed for the presence and severity of osteophytes, end plate sclerosis, and disc space narrowing. Linear regression was used to determine the association between each of these features and BMD at the spine and hip, with adjustments for age, body mass index, and levels of physical activity. Analyses were done separately in men and women.Results: 250 women and 256 men ( mean age around 65 years) were studied. At the lumbar spine, after age adjustment there was an increase in BMD with increasing grade for all radiographic features of disc degeneration in both men and women. At the femoral neck, after age adjustment there was an increase in BMD with increasing osteophyte and end plate sclerosis grade though not disc space narrowing. Adjusting for body mass index and physical activity did not influence the strength of the associations.Conclusions: Radiographic features of lumbar disc degeneration are associated with an increase in BMD at the spine. Osteophytes and end plate sclerosis, but not disc space narrowing, are associated with an increase in BMD at the hip.