Androgen-induced lncRNA POTEF-AS1 regulates apoptosis-related pathway to facilitate cell survival in prostate cancer cells.
Androgen-induced lncRNA POTEF-AS1 regulates apoptosis-related pathway to facilitate cell survival in prostate cancer cells.
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DOI：
10.1111/cas.13151
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发表时间：
2017-03
期刊：
影响因子：
5.7
通讯作者：
Inoue S
中科院分区：
文献类型：
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作者：
Misawa A;Takayama KI;Fujimura T;Homma Y;Suzuki Y;Inoue S
尽管长链非编码RNA（lncRNA）与多种癌症相关，但lncRNA与前列腺癌中雄激素受体信号传导之间的相互作用仍不清楚。我们通过定向 RNA 测序分析，鉴定了一种雄激素依赖性 lncRNA，POTEF-AS1，其表达受两个雄激素依赖性细胞中雄激素受体的调节。 POTEF-AS1 促进细胞生长，抑制与 Toll 样受体信号传导和凋亡途径相关的基因，并抑制多西他赛处理的 LNCaP 细胞的凋亡。这些发现表明 POTEF-AS1 通过抑制 Toll 样受体信号传导在前列腺癌的进展中发挥关键作用。
Although long non‐coding RNAs (lncRNAs) have been associated with a variety of cancers, the interplay between lncRNAs and androgen receptor signaling in prostate cancer is still unclear. We identified an androgen‐dependent lncRNA , POTEF‐AS1, whose expression was regulated by androgen receptor in two androgen‐dependent cells by using directional RNA sequencing analysis. POTEF‐AS1 promoted cell growth, repressed genes related to the Toll‐like receptor signaling and apoptosis pathways, and inhibited apoptosis in docetaxel‐treated LNCaP cells. These findings suggest that POTEF‐AS1 would play a key role in the progression of prostate cancer by repressing Toll‐like receptor signaling.