Youth-specific considerations in the development of preexposure prophylaxis, microbicide, and vaccine research trials.
Youth-specific considerations in the development of preexposure prophylaxis, microbicide, and vaccine research trials.
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DOI：
10.1097/qai.0b013e3181e3a922
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
McGowan I
中科院分区：
文献类型：
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作者：
Rudy BJ;Kapogiannis BG;Lally MA;Gray GE;Bekker LG;Krogstad P;McGowan I
Preventing HIV infection in adolescents and young adults will require a multimodal, targeted approach including individual-directed behavioral risk reduction, community-level structural change, and biomedical interventions to prevent sexual transmission. Trials testing biomedical interventions to prevent HIV transmission will require special attention in this population due to the unique psychosocial as well as physiologic characteristics that differentiate them from older populations. For example, microbicide research will need to consider acceptability, dosing requirements, and co-infection rates that are unique to this population. Pre-exposure prophylaxis studies also will need to consider potential unique psychosocial issues such as sexual disinhibition and acceptability as well as unique pharmacokinetic parameters of antiretroviral agents. Vaccine trials also face unique issues with this population, including attitudes towards vaccines, risks related to false-positive HIV tests related to vaccine, and different immune responses based on more robust immunity. In this paper, we will discuss issues around implementing each of these biomedical prevention modalities in trials among adolescents and young adults to help to guide future successful research targeting this population.
