SOX2 Is a Marker for Stem-like Tumor Cells in Bladder Cancer.
SOX2 Is a Marker for Stem-like Tumor Cells in Bladder Cancer.
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SOX2 是膀胱癌中干细胞样肿瘤细胞的标记物。
DOI：
10.1016/j.stemcr.2017.07.004
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发表时间：
2017-08-08
影响因子：
5.9
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Zhu F;Qian W;Zhang H;Liang Y;Wu M;Zhang Y;Zhang X;Gao Q;Li Y
据报道，人类膀胱癌（BCa）中存在功能不同的癌症干细胞（CSC）。在这里，我们发现 Sox2（一种被充分表征为干细胞标记的转录因子）在小鼠和人类 BCa 中表达上调。 Sox2 在正常尿路上皮细胞中不表达，但在肿瘤前期膀胱肿瘤中开始表达，并在侵袭性小鼠 BCa 中继续表达。使用 s 作为 Sox2 转录表达的报告基因，我们证明表达 Sox2 的细胞标记了促进已建立的 BCa 生长的肿瘤细胞亚群。 SOX2 阳性细胞还表达其他先前报道的 BCa CSC 标记物，包括 Keratin14 (KRT14) 和 CD44v6。原发性侵袭性 BCa 内表达 Sox2 的细胞的消融导致肿瘤消退增强，支持 SOX2 阳性细胞在调节 BCa 维持和进展中的重要作用。我们的数据显示 Sox2 是膀胱 CSC 的标志物，并表明它是 BCa 治疗的潜在临床靶点。 Sox2 表达标志着体内膀胱癌干细胞 SOX2 阳性细胞是表达 KRT14 的癌症干细胞的亚群 SOX2 阳性细胞是表达 CD44v6 的癌症干细胞的亚群 消除 Sox2 表达细胞可减少膀胱癌进展 在本文中，Yang 及其同事评估了表达 Sox2 的更新和分化潜力 膀胱癌细胞，通过体外克隆实验、体内移植和谱系追踪实验。他们的数据表明，Sox2 的表达标记了膀胱癌干细胞，这对于肿瘤的生长和维持是必需的。
It has been reported that functionally distinct cancer stem cells (CSCs) exist in human bladder cancer (BCa). Here, we found that Sox2, a transcription factor that is well characterized as a marker for stem cells, is upregulated in both mouse and human BCa. Sox2 expression is absent in normal urothelial cells, but it begins to be expressed in pre-neoplastic bladder tumors and continues to be expressed in invasive mouse BCa. Using s as a reporter of Sox2 transcriptional expression, we demonstrated that Sox2-expressing cells mark a subpopulation of tumor cells that fuel the growth of established BCa. SOX2-positive cells also expressed other previously reported BCa CSC markers, including Keratin14 (KRT14) and CD44v6. Ablation of Sox2-expressing cells within primary invasive BCa led to enhanced tumor regression, supporting the essential role of SOX2-positive cells in regulating BCa maintenance and progression. Our data show that Sox2 is a marker of bladder CSCs and indicate it as a potential clinical target for BCa therapy. Sox2 expression marks bladder cancer stem cells in vivo SOX2-positive cells are a subpopulation of KRT14-expressing cancer stem cells SOX2-positive cells are a subpopulation of CD44v6-expressing cancer stem cells Elimination of Sox2-expressing cells led to reduction of bladder cancer progression In this article, Yang and colleagues assess the renewal and differentiation potential of Sox2-expressing cells in bladder cancer, by in vitro clonogenic assays, in vivo transplantation, and lineage-tracing experiments. Their data indicate that Sox2 expression marks the bladder cancer stem cells, which are necessary for tumor growth and maintenance.
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影响因子：
11.2
作者：
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通讯作者：
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作者：
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DOI：
10.1073/pnas.0906549106
发表时间：
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