High rates of false-positive hepatitis C antibody tests can occur after left ventricular assist device implantation.
High rates of false-positive hepatitis C antibody tests can occur after left ventricular assist device implantation.
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左心室辅助装置植入后丙型肝炎抗体检测假阳性率可能很高。
DOI：
10.1097/mat.0b013e3182a53d00
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Lanfear,DavidE
中科院分区：
文献类型：
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作者：
Srivastava,AjayV;Hrobowski,Tara;Krese,Lori;Huang,MaryAnn;Nemeh,Hasan;Tita,Cristina;Williams,Celeste;Brewer,Robert;Lanfear,DavidE
在心脏移植前，丙型肝炎病毒（HCV）筛查是常规的，在大多数中心，病毒的存在是一种排除。左心室辅助装置（LVAD）通常用作移植的桥梁，并引起免疫激活。我们收集了2006年1月至2008年2月在一家中心接受LVAD置入的32例连续患者的数据。在LVAD前后进行HCV检测的23例潜在的移植桥患者中，7例（30%）HCV抗体呈阳性，但在确证性检测中没有真正的HCV感染。心脏移植护理提供者应该意识到在这种情况下可能出现的假阳性HCV抗体检测。
Hepatitis C virus (HCV) screening is routine before cardiac transplantation, and virus presence is an exclusion at most centers. Left ventricular assist devices (LVADs) are often used as a bridge to transplantation and cause immune activation. We collected data on 32 consecutive patients undergoing LVAD placement between January 2006 and February 2008 at a single center. Of the 23 potential bridge-to-transplant patients with HCV testing before and after LVAD, seven (30%) turned positive for HCV antibody but did not have true HCV infection on confirmatory testing. Cardiac transplant care providers should be aware of possible false-positive HCV antibody tests in this setting.