Identification of novel bivalent mimetics of annonaceous acetogenins via a scaffold-hopping strategy.
Identification of novel bivalent mimetics of annonaceous acetogenins via a scaffold-hopping strategy.
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通过支架跳跃策略鉴定番荔枝苷的新型二价模拟物。
DOI：
10.1016/j.bmcl.2014.02.072
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发表时间：
2014
影响因子：
2.7
通讯作者：
Sheng Jiang
中科院分区：
文献类型：
--
作者：
Yanghan Liu;Yongqiang Liu;Zhen Li;Guangbiao Zhou;Z. Yao;Sheng Jiang
本文设计、合成并评价了一系列新型的二价拟多糖。其中，与AA005相比，化合物7对癌细胞的生长抑制活性更强，对正常细胞的选择性更高。这项工作表明，中间哌嗪环的修饰是简化乙酰原模拟物的有效优化工具。
A series of novel bivalent mimetics of annonaceous acetogenins have been designed, synthesized, and evaluated. Among these, compound7bearing a homopiperazine ring in the middle region exhibited more potent growth inhibitory activity and higher selectivity against cancer cells over normal cells by comparison with AA005. This work indicates that modification of the middle piperazine ring is a useful optimizing tool for the simplified acetogenin mimetics.
影响因子：
15
作者：
Gestwicki, JE;Cairo, CW;Kiessling, LL
通讯作者：
Kiessling, LL
影响因子：
5.1
作者：
LANDOLT, JL;AHAMMADSAHIB, KI;MCLAUGHLIN, JL
通讯作者：
MCLAUGHLIN, JL