Autoantibodies to interferon-γ in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity
Autoantibodies to interferon-γ in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity
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DOI：
10.1086/380453
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发表时间：
2004-01-01
影响因子：
11.8
通讯作者：
Kumararatne, DS
中科院分区：
文献类型：
--
作者：
Döffinger, R;Helbert, MR;Kumararatne, DS
我们评估了一个病人与播散型结核分枝杆菌和龟分枝杆菌感染，其中他死亡。他还患上了自身免疫性（I型）糖尿病和原发性甲状腺功能减退症。他的血清中含有高滴度的免疫球蛋白G自身抗体干扰素-γ（IFN-γ），能够阻断体外反应，这种细胞因子的外周血单核细胞从正常的捐助者。这些结果表明，IFN-γ自身抗体可以诱导易感性播散性分枝杆菌感染，这可能是难治性化疗。
We evaluated a patient with disseminated Mycobacterium tuberculosis and Mycobacterium chelonae infection, of which he died. He also developed autoimmune ( type I) diabetes and primary hypothyroidism. His serum contained a high titer of immunoglobulin G autoantibody to interferon-gamma ( IFN-gamma) capable of blocking in vitro responses to this cytokine by peripheral blood mononuclear cells from normal donors. These results suggest that autoantibodies to IFN-gamma can induce susceptibility to disseminated mycobacterial infection, which may be refractory to chemotherapy.