Smoking and Increased White and Red Blood Cells A Mendelian Randomization Approach in the Copenhagen General Population Study
Smoking and Increased White and Red Blood Cells A Mendelian Randomization Approach in the Copenhagen General Population Study
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吸烟与白色和红细胞增多：哥本哈根一般人群研究中的孟德尔随机化方法
DOI：
10.1161/atvbaha.118.312338
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发表时间：
2019-05-01
影响因子：
8.7
通讯作者：
Nordestgaard, Borge Gronne
中科院分区：
文献类型：
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作者：
Pedersen, Kasper Monsted;Colak, Yunus;Nordestgaard, Borge Gronne
吸烟是否会对白色和红细胞以及血小板计数产生因果影响尚不清楚。使用孟德尔随机化方法，我们测试了吸烟导致这些血细胞指数增加的假设。方法和结果-我们纳入了哥本哈根一般人群研究中年龄在20 - 100岁之间的104 607名白色丹麦人，这些人的信息包括血细胞指数、吸烟习惯和CHRNA 3（α 3烟碱胆碱能受体）rs 1051730基因型，其中T等位基因导致更高的烟草消费; 41 759人为既往吸烟者，17 852人为当前吸烟者。在多变量校正的观察分析中，与从不吸烟者相比，白色血细胞增加高达19%，血小板增加高达4.7%，红细胞指数增加高达2.3%。所有的关联都是剂量依赖性的，烟草消费，但白色血细胞和血小板也依赖于戒烟时间的前吸烟者;最高的增加是< 1-year smoking cessation and lowest increases for >10年的戒烟。在年龄和性别调整的遗传分析中，目前吸烟者中每增加一个T等位基因的百分比差异为1.15%。（95% CI，0.61%-1.68%）白细胞，1.07%（0.38%-1.76%）中性粒细胞，1.34%（0.66%-2.02%）淋巴细胞，1.50%（0.83%-2.18%）单核细胞，-0.60%（-1.91%至0.74%）嗜酸性粒细胞，0.17%（-0.94%至1.29%）嗜碱性粒细胞，0.38%（-0.17%至0.93%）血小板，0.04%（-0.14%至0.23%），红细胞压积为0.34%（0.17%至0.50%），血红蛋白为0.26%（0.09%至0.43%），平均红细胞体积为0.29%（0.18%至0.41%）。结论：吸烟导致血液中白细胞、中性粒细胞、淋巴细胞和单核细胞增加，以及红细胞压积、血红蛋白和平均红细胞体积增加。观察吸烟关系是长期的白色血细胞和短期的红细胞指数。
Objective-Whether tobacco smoking causally affects white and red blood cells and thrombocyte counts is unknown. Using a Mendelian randomization approach, we tested the hypothesis that smoking causes increases in these blood cell indices. Approach and Results-We included 104 607 white Danes aged 20 to 100 years from the Copenhagen General Population Study with information on blood cell indices, smoking habits, and CHRNA3 (alpha 3 nicotinic cholinergic receptor) rs1051730 genotype, where the T allele causes higher tobacco consumption; 41 759 were former smokers and 17 852 current smokers. In multivariable adjusted observational analyses and compared with never smokers, white blood cells were associated with up to 19% increases, thrombocytes with up to 4.7% increases, and red blood cell indices with up to 2.3% increases in former and current smokers. All associations were dose dependent, with tobacco consumption but for white blood cells and thrombocytes also dependent on smoking cessation time in former smokers; highest increases were for < 1-year smoking cessation and lowest increases for > 10-year smoking cessation. In age-and sex-adjusted genetic analyses, percent differences per T allele increase in current smokers were 1.15% (95% CI, 0.61%-1.68%) for leukocytes, 1.07% (0.38%-1.76%) for neutrophils, 1.34% (0.66%-2.02%) for lymphocytes, 1.50% (0.83%-2.18%) for monocytes, -0.60% (-1.91% to 0.74%) for eosinophils, 0.17% (-0.94% to 1.29%) for basophils, 0.38% (-0.17% to 0.93%) for thrombocytes, 0.04% (-0.14% to 0.23%) for erythrocytes, 0.34% (0.17% to 0.50%) for hematocrit, 0.26% (0.09% to 0.43%) for hemoglobin, and 0.29% (0.18% to 0.41%) for mean corpuscular volume. Conclusions-Smoking causes increased blood leukocytes, neutrophils, lymphocytes, and monocytes, as well as increased hematocrit, hemoglobin, and mean corpuscular volume. The observational smoking relationships were long term for white blood cells and short term for red blood cell indices.