A postnatal sensitive period for plasticity of cortical afferents but not cortical association fibers in rat piriform cortex
A postnatal sensitive period for plasticity of cortical afferents but not cortical association fibers in rat piriform cortex
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DOI：
10.1016/s0006-8993(02)03847-7
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发表时间：
2003-01-24
期刊：
影响因子：
2.9
通讯作者：
Wilson, DA
中科院分区：
文献类型：
--
作者：
Best, AR;Wilson, DA
雄性和雌性大鼠在出生后第1天（PN）或PN 30后接受单侧鼻孔闭塞或假手术。在单侧嗅觉剥夺至少30天后，将大鼠乌拉坦麻醉，并从前梨状皮质（aPCX）进行记录。电击刺激传入纤维（外侧嗅束）和联合/连合纤维诱发的场电位在aPCX中进行了分析，各组和年龄之间。结果表明，早发性单侧嗅觉剥夺抑制场电位的刺激被剥夺的皮层传入，而迟发性剥夺没有。与此相反，皮层内关联纤维介导的场电位在剥夺皮层增强后，早发性和迟发性剥夺。这些结果表明，传入和协会纤维通路的古皮层，反映了先前描述的新皮层感觉系统的差异发育可塑性。(C)2002 Elsevier Science B. V.保留所有权利。
Male and female rats underwent unilateral naris occlusion or sham surgery on either post-natal day (PN) 1 or after PN30. Following at least 30 days of unilateral olfactory deprivation, rats were urethane anesthetized and recordings were made from anterior piriform cortex (aPCX). Shock stimulation of afferent fibers (lateral olfactory tract) and association/commissural fibers evoked field potentials in aPCX that were analyzed across groups and between ages. The results demonstrate that early-onset unilateral olfactory deprivation depresses field potentials evoked by stimulation of the deprived cortical afferent, while late-onset deprivation did not. In contrast, intracortical association fiber mediated field potentials in the deprived cortex were enhanced after both early-onset and late-onset deprivation. These results suggest differential developmental plasticity of afferent and association fiber pathways in paleocortex that mirrors that previously described in neocortical sensory systems. (C) 2002 Elsevier Science B.V. All rights reserved.