Non-alcoholic fatty liver disease prevalence among school-aged children and adolescents in Iran and its association with biochemical and anthropometric measures
Non-alcoholic fatty liver disease prevalence among school-aged children and adolescents in Iran and its association with biochemical and anthropometric measures
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DOI：
10.1111/j.1478-3231.2008.01790.x
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发表时间：
2009-02-01
影响因子：
6.7
通讯作者：
Hajarizadeh, Behzad
中科院分区：
文献类型：
--
作者：
Alavian, Seyed-Moayed;Mohammad-Alizadeh, Amir-Hooshang;Hajarizadeh, Behzad
为了调查伊朗学龄儿童和青少年中非酒精性脂肪性肝病(NAFLD)的患病率以及相关代谢异常的确定，2007年对伊朗966名7-18岁儿童进行了横断面调查。这些儿童接受了完整的人体测量和实验室测量，并进行了腹部超声检查，以了解肝脏的回声和大小。问卷调查还包括人口学和医学史、饮食习惯、饮酒和吸烟情况。7.1%的儿童通过超声诊断为脂肪肝。丙氨酸氨基转移酶(ALT)升高的发生率为1.8%。非酒精性脂肪肝在老年组中更为常见(12.5%比3.5%，P<；0.0001)。ALT升高、空腹胰岛素升高、总胆固醇、低密度脂蛋白胆固醇、甘油三酯和胰岛素抵抗儿童NAFLD的优势比(OR)分别为10.9(3.9~30.4)、2.8(1.6~4.8)、2.8(1.5~5.1)、2.8(1.5~5.3)、2.5(1.3~4.8)和4.4(1.6~12.3)。因此，NAFLD与年龄、ALT、空腹胰岛素、总胆固醇、低密度脂蛋白、甘油三酯和IR显著相关。多因素Logistic回归分析显示，ALT(OR=1.2P<；0.01)、总胆固醇(OR=1.01；P<；0.01)和腰围(OR=1.14，P<；0.0001)是预测非酒精性脂肪肝的独立代谢因素。如果对儿童进行腰围、空腹血糖、空腹胰岛素和血脂谱等变量的评估，以筛查那些易患NAFLD的人，这将是非常有用的。
To investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) as well as the determination of associated metabolic abnormalities in Iranian school-aged children and adolescents.Data were obtained from 966 children aged 7-18 years in Iran by a cross-sectional survey in 2007. These children were subjected to a complete anthropometric and laboratory measurement and abdominal ultrasonography for liver echogenicity and size. A questionnaire was also used to obtain information on demographical and medical history, dietary habit, alcohol consumption and cigarette smoking.Fatty liver was diagnosed by ultrasound in 7.1% of children. The prevalence of elevated alanine aminotransferase (ALT) was 1.8%. NAFLD was significantly more common in the older group (12.5 against 3.5%, P < 0.0001). The odds ratios (OR) (95% confidence interval) for NAFLD in children having elevated ALT, high fasting insulin, total cholesterol, low density lipoprotein (LDL) cholesterol, triglyceride and insulin resistance (IR) were 10.9 (3.9-30.4), 2.8 (1.6-4.8), 2.8 (1.5-5.1), 2.8 (1.5-5.3), 2.5 (1.3-4.8) and 4.4 (1.6-12.3) respectively. Therefore, NAFLD was significantly associated with increasing age, ALT, fasting insulin, total cholesterol, LDL cholesterol, triglyceride and IR. In multiple logistic regression analysis, ALT (OR=1.2; P < 0.01), total cholesterol (OR=1.01; P < 0.01) and waist circumference (OR=1.14, P < 0.0001) were independent metabolic factors predictive of NAFLD after adjustment for other variables.There was a strong relationship between NAFLD and the abnormal metabolic variables in children. It will be very useful if children are assessed for variables such as waist circumference, fasting blood sugar, fasting insulin and serum lipid profile in order to screen those susceptible to NAFLD.