ON THE ROLE OF INTRAMURAL NERVES IN THE PATHOGENESIS OF CHOLERA TOXIN-INDUCED INTESTINAL SECRETION
ON THE ROLE OF INTRAMURAL NERVES IN THE PATHOGENESIS OF CHOLERA TOXIN-INDUCED INTESTINAL SECRETION
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DOI：
10.3109/00365528109181984
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发表时间：
1981-01-01
影响因子：
1.9
通讯作者：
LUNDGREN, O
中科院分区：
文献类型：
--
作者：
CASSUTO, J;JODAL, M;LUNDGREN, O
在麻醉的猫和大鼠中，通过将分离的肠段暴露于霍乱肠毒素来产生肠分泌物。在肠段溶液中加入神经传导阻滞剂河豚毒素或局部麻醉剂利多卡因，可明显抑制胆汁分泌率，在大多数实验中观察到液体的净吸收。肠壁内神经机制可能参与了霍乱分泌物的发病机制。
Intestinal secretion was produced in anesthetized cats and rats by exposing isolated intestinal segments to cholera enterotoxin. Giving tetrodotoxin, a nerve-conduction-blocking agent, or adding lidocaine, a local anesthetic agent, to the solution in the intestinal segments markedly inhibited the rate of choleraic secretion and in most experiments a net absorption of fluid was observed. Intramural nervous mechanisms are probably involved in the pathogenesis of choleraic secretion.