THE INTERACTION OF MAMMALIAN REOVIRUSES WITH THE CYTOSKELETON OF MONKEY KIDNEY CV-1 CELLS
THE INTERACTION OF MAMMALIAN REOVIRUSES WITH THE CYTOSKELETON OF MONKEY KIDNEY CV-1 CELLS
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DOI：
10.1016/0042-6822(82)90040-x
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发表时间：
1982-01-01
期刊：
影响因子：
3.7
通讯作者：
FIELDS, BN
中科院分区：
文献类型：
--
作者：
SHARPE, AH;CHEN, LB;FIELDS, BN
研究呼肠孤病毒感染对CV-1细胞骨架的影响。呼肠孤病毒感染在CV-1细胞中产生静脉蛋白丝的主要破坏，而不产生可识别的微管或微丝束的破坏。呼肠孤病毒感染除了破坏血凝蛋白丝的组织外，似乎还会引起血凝蛋白丝的重组。病毒包涵体含有波形蛋白丝状结构。病毒感染也会改变线粒体的细胞质分布，这与所提出的蛋白丝在决定线粒体分布中的作用是一致的。
The effect of reovirus infection on the CV-1 cytoskeleton was examined. Reovirus infection produces a major disruption of vimentin filaments without producing a discernable disorganization of microtubules or microfilament bundles in CV-1 cells. In addition to disrupting the organization of vimentin filaments, reovirus infection appears to cause a reorganization of vimentin filaments. Viral inclusions contain vimentin filamentous structures. Viral infection also alters the cytoplasmic distribution of mitochondria, consistent with the proposed role of vimentin filaments in determining the distribution of mitochondria.