Association of inflammatory cytokines with mortality in peritoneal dialysis patients.
Association of inflammatory cytokines with mortality in peritoneal dialysis patients.
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DOI：
10.1051/bmdcn/2017070101
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发表时间：
2017-03
期刊：
影响因子：
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通讯作者：
Huang CC
中科院分区：
文献类型：
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作者：
Liu YL;Liu JH;Wang IK;Ju SW;Yu TM;Chen IR;Liu YC;Huang CM;Lin SY;Chang CT;Huang CC
目的：先前关于促炎细胞因子与 PD 人群死亡率之间关系的研究有限。我们的目的是在这里进行调查。方法：共有 50 名接受偶发 PD 的患者纳入本研究。我们测量了促炎细胞因子白细胞介素 18 (IL-18)、白细胞介素 6 (IL-6) 和白细胞介素 1ß (IL-1ß) 的滴度。研究结果包括全因死亡率、心血管相关死亡率和感染引起的死亡率。使用Cox回归模型。结果：在这项为期 7 年的前瞻性研究中，IL-18 ≥ 804.3pg/ml、IL-6 ≥ 3.92 pg/ml、IL-1ß ≥ 0.86pg/ml、年龄≥ 50 岁和是否患有糖尿病可作为 PD 患者死亡率的个体显着预测因子。 PD 第一年内较高的 IL-6 滴度与较低的平均白蛋白水平相关。这些死亡风险标记数量的增加与生存优势的降低相关（P = 0.001）。结论：PD 治疗开始时年龄≥50 岁、糖尿病和炎症细胞因子谱可以预测 PD 人群的 7 年死亡率。
Aims: Previous study on association between pro-inflammatory cytokines and mortality in PD population is limited. We aimed to investigate here. Methods: Total 50 patients who underwent incident PD were enrolled in this study. We measured the titers of pro-inflammatory cytokines Interleukin-18(IL-18), Interleukin-6 (IL-6), and Interleukin-1ß (IL-1ß). Study outcomes were all-cause mortality, cardiovascular-related mortality, and infection-caused mortality. Cox-regression model was used. Results: In this 7 year prospective study, IL-18 ≥ 804.3pg/ml, IL-6 ≥ 3.92 pg/ml, IL-1ß ≥ 0.86pg/ml, age ≥ 50 years-old, and existence of diabetes could be used as individual significant predictors for mortality in PD patients. Higher titers of IL-6 were associated with lower averaging albumin levels within 1st year of PD. Increasing numbers of these risk markers of mortality was associated with decreasing survival advantages (P = 0.001). Conclusion: Age ≥ 50 years-old, diabetes, and inflammatory cytokines profiles at the start of PD therapy could predict for 7-year mortality in PD population.