Normal human bronchial immunoglobulins and proteins: effects of cigarette smoking.
Normal human bronchial immunoglobulins and proteins: effects of cigarette smoking.
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正常人支气管免疫球蛋白和蛋白质：吸烟的影响。
DOI：
10.1164/arrd.1977.116.1.25
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
R. Rossen
中科院分区：
文献类型：
--
作者：
G. Warr;R. Martin;P. Sharp;R. Rossen
从36名健康非吸烟者和19名健康吸烟者的支气管灌洗液中选择的蛋白质进行了比较。虽然吸烟者灌洗的液体中含有4倍于非吸烟者的细胞（80%以上的巨噬细胞），但两组之间在免疫球蛋白A、α 1-抗胰蛋白酶、α 2-球蛋白、转铁蛋白或白蛋白含量方面没有定量差异。然而，吸烟者支气管液中的免疫球蛋白G含量是不吸烟者的两倍。这种免疫球蛋白的选择性增加与刺激局部支气管免疫球蛋白产生或响应于吸入香烟烟雾而将血浆免疫球蛋白选择性渗出到肺泡腔中是相容的。
Selected proteins were compared in bronchial lavage fluids recovered from 36 healthy nonsmokers and 19 healthy cigarette smokers. Although fluids lavaged from smokers contained 4 times as many cells (more than 80 per cent macrophages) as fluids from nonsmokers, there were no quantitative differences between the two groups in immunoglobulin A, a1-antitrypsin, a2-globulin, transferrin, or albumin content. However, immunoglobulin G content of bronchial fluids from smokers was twice as high as that from nonsmokers. This selective increase in immunoglobulin is compatible either with stimulated local bronchial immunoglobulin production or the selective exudation of plasma immunoglobulin into alveolar spaces in response to inhaled cigarette smoke.