SYNTHESIS OF PEPTIDES BY THE SOLID-PHASE METHOD. 6. NEUROTENSIN, FRAGMENTS, AND ANALOGS
SYNTHESIS OF PEPTIDES BY THE SOLID-PHASE METHOD. 6. NEUROTENSIN, FRAGMENTS, AND ANALOGS
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固相法合成肽。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
F. Rioux
中科院分区：
文献类型：
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作者：
S. St.;J. Lalonde;M. Gendreau;R. Quirion;D. Regoli;F. Rioux
用固相法制备了神经降压素（NT）及其24个相关化合物，包括在母体分子C-末端修饰的片段或类似物。经阳离子交换层析纯化后，化合物通过薄层层析、氨基酸分析、元素分析和高压液相色谱进行了表征。在大鼠胃条、豚鼠离体自发搏动心房和灌流大鼠心脏冠状动脉中评价肽的刺激作用。这些化合物的生物活性之间的差异进行了讨论。
Neurotensin (NT) and 24 related compounds, including fragments or analogues modified at the C-terminal end of the parent molecule, have been prepared by the solid-phase method. After purification by cation-exchange chromatography, the compounds were characterized by thin-layer chromatography, amino acid analysis, elemental analysis, and high-pressure liquid chromatography. The stimulating effects of the peptides were evaluated in rat stomach strips, in isolated spontaneously beating atria of guinea pigs, and in the coronaries of perfused rat hearts. The differences between the biological activities of these compounds are discussed.