Diffuse large B-cell lymphoma in the spinal epidural space: A study of the Osaka Lymphoma Study Group
Diffuse large B-cell lymphoma in the spinal epidural space: A study of the Osaka Lymphoma Study Group
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DOI：
10.1016/j.prp.2010.02.003
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发表时间：
2010-01-01
影响因子：
2.8
通讯作者：
Aozasa, Katsuyuki
中科院分区：
文献类型：
--
作者：
Wada, Naoki;Kohara, Masaharu;Aozasa, Katsuyuki
弥漫性大b细胞淋巴瘤（DLBCL）累及脊髓硬膜外间隙（SEDLBCL）相对罕见，占日本大阪DLBCL的18%。本研究的目的是分析SEDLBCL病例的临床和组织病理学表现，包括与eb病毒（EBV）的关系和免疫组织化学特征。男性16例，女性11例，年龄37 ~ 86岁，中位64岁。I期8例，II期3例，I期5例，IV期11例。根据抗cd10、bcl-6和um -1的染色模式，将病例分为生发中心b细胞（GCB）型17例，非GCB型9例。肿瘤细胞EBV阳性率为4%，与淋巴结性DLBCL相比，SEDLBCL患者表现为高表现状态（PS）的频率更高。与中枢神经系统（CNS）的DLBCL比较。高分期、结外2个及以上病变、高国际预后指数（IPI）和gcb型在SEDLBCL中发生率更高。SEDLBCL与淋巴结/中枢神经系统DLBCL在组织学特征上无显著差异。单因素分析显示，晚期是影响总生存的不利因素（P=0.060）。SEDLBCL不同于节点型和CNS型DLBCL，但不太可能在每个组中都与EBV相关(C) 2010 Elsevier GmbH All rights reserved
Diffuse large B-cell lymphoma (DLBCL) involving spinal epidural space (SEDLBCL) is relatively rare, constituting 1 8% of DLBCLs in Osaka, Japan The aim of this study was to analyze SEDLBCL cases for their clinical and histopathologic findings, including an association with Epstein-Barr virus (EBV) and immunohistochemical characteristicsWe analyzed the clinicopathologic findings of 27 SEDLBCL cases. They consisted of 16 males and 11 females, their age ranging from 37-86 years (median 64 years). Eight patients had stage I disease, 3 had stage II, 5 had stage Ill, and 11 had stage IV Based on the staining pattern for anti-CD 10, bcl-6, and MUM-1, the cases were categorized into 17 cases of the germinal center B-cell (GCB) type and nine of the non-GCB type There was a 4%-positive rate for EBV in the tumor cells When compared to nodal DLBCL, the frequency of patients with a high performance status (PS) is higher in SEDLBCL. Compared to the DLBCL of the central nervous system (CNS). the frequency of cases with high stage, 2 or more extranodal lesions, high international prognostic index (IPI), and GCB-type is higher in SEDLBCL There were no significant differences in the histologic features between SEDLBCL and nodal/CNS DLBCL. Univariate analysis revealed that advanced stage was an unfavorable factor for overall survival (P=0.060).SEDLBCL is different from nodal and CNS DLBCL, but an association with EBV is unlikely in every group (C) 2010 Elsevier GmbH All rights reserved