A generic constitutive model for the passive porcine coronary artery
A generic constitutive model for the passive porcine coronary artery
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DOI：
10.1007/s10237-010-0231-9
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发表时间：
2011-04-01
影响因子：
3.5
通讯作者：
van de Vosse, Frans N.
中科院分区：
文献类型：
--
作者：
van den Broek, Chantal N.;van der Horst, Arjen;van de Vosse, Frans N.
描述动脉力学行为的本构模型在导管产品的开发中很重要，用于具有特定半径的动脉。证明可能存在的本构模型,提供了一套通用的材料和几何参数,能够预测冠状动脉的radius-specific力学行为,被动pressure-inner半径(P-r(我))和压轴向力变化(pδF (z))关系的七个猪冠状动脉左前降枝测定体外设置和配备的模型Driessen等人127年> Eng (3): 494 - 503 (2005),生物力学学报7(2):93-103（2008）。此外，测定了每条动脉在生理负荷下的胶原体积分数、生理轴向预拉伸和壁厚与内半径之比。由此得到两个通用参数集，每个参数集包括四个材料参数和三个几何参数。这些通用集用于计算每个测试动脉的变形，在生理负荷下使用单个半径测量作为动脉特异性输入。与体外测量的关系相比，预测动脉特异性P-r (i)和p - δ F (z)关系的平均准确性为32 μ m（2.3%）和6 mN（相对于δ F (z)范围）。结果表明，本研究建立的具有通用参数的本构模型能够较好地预测动脉的力学行为。
Constitutive models describing the arterial mechanical behavior are important in the development of catheterization products, to be used in arteries with a specific radius. To prove the possible existence of a constitutive model that, provided with a generic set of material and geometric parameters, is able to predict the radius-specific mechanical behavior of a coronary artery, the passive pressure-inner radius (P-r (i) ) and pressure-axial force change (P-Delta F (z) ) relations of seven porcine left anterior descending coronary arteries were measured in an in-vitro set-up and fitted with the model of Driessen et al. in J Biomech Eng 127(3):494-503 (2005), Biomech Model Mechanobiol 7(2):93-103 (2008). Additionally, the collagen volume fraction, physiological axial pre-stretch, and wall thickness to inner radius ratio at physiological loading were determined for each artery. From this, two generic parameter sets, each comprising four material and three geometric parameters, were obtained. These generic sets were used to compute the deformation of each tested artery using a single radius measurement at physiological loading as an artery-specific input. Artery-specific P-r (i) and P-Delta F (z) relations were predicted with an accuracy of 32 mu m (2.3%) and 6 mN (29% relative to Delta F (z) -range) on average compared to the relations measured in-vitro. It was concluded that the constitutive model provided with the generic parameters found in this study can well predict artery-specific mechanical behavior.