TCTP overexpression is associated with the development and progression of glioma
TCTP overexpression is associated with the development and progression of glioma
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TCTP过表达与胶质瘤的发生和进展相关
DOI：
10.1007/s13277-013-0906-9
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发表时间：
2013-12-01
期刊：
影响因子：
--
通讯作者：
Guo, Guo-Zhen
中科院分区：
文献类型：
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作者：
Miao, Xia;Chen, Yong-Bin;Guo, Guo-Zhen
翻译控制的肿瘤蛋白(TCTP)在多种恶性肿瘤中表达上调已有报道。然而，TCTP对胶质瘤的影响尚不清楚。本研究的目的是探讨TCTP在脑胶质瘤中的表达及其预后价值。免疫印迹法检测TCTP在45例脑胶质瘤和22例正常脑组织中的表达。应用免疫组织化学方法对127例脑胶质瘤组织芯片进行检测，分析TCTP表达与临床病理特征的关系。与正常脑组织相比，胶质瘤组织中TCTP的表达显著升高(p<；0.001)。此外，胶质瘤组织中TCTP的高表达与肿瘤的病理分级密切相关(p= 0.018)。Kaplan-Meier分析显示，胶质瘤和TCTP表达较高的患者总体生存时间较短(p<；0.001)。在多因素分析中，TCTP的表达被证明是胶质瘤患者的一个独立的预后因素(p<；0.001)。综上所述，本研究证实了TCTP在胶质瘤中的过度表达及其与肿瘤进展的关系。首次证明TCTP在脑胶质瘤中的表达是一个独立的预后因素，可能成为脑胶质瘤的一个潜在的诊断和治疗靶点。
Upregulation of translationally controlled tumor protein (TCTP) has been reported in a variety of malignant tumors. However, the impact of TCTP in glioma remains unclear. The objective of this study was to investigate the expression and prognostic value of TCTP in glioma patients. Western blot analysis was used to characterize the expression patterns of TCTP in 45 glioma and 22 normal brain tissues. Immunohistochemistry on a tissue microarray containing 127 cases of glioma was performed to analyze the association between TCTP expression and clinicopathological features. Compared with normal brain tissues, TCTP expression was significantly higher in glioma tissues (p<0.001). In addition, high TCTP expression in glioma was significantly associated with advanced pathological grade (p= 0.018). Kaplan–Meier analysis showed that patients with glioma and higher TCTP expression tend to have shorter overall survival time (p<0.001). In multivariate analysis, TCTP expression was proved to be an independent prognostic factor for patients with glioma (p<0.001). In conclusion, this study confirmed the overexpression of TCTP and its association with tumor progression in glioma. It also provided the first evidence that TCTP expression in glioma was an independent prognostic factor of patients, which might be a potential diagnostic and therapeutic target of glioma.