Normal childhood brain growth and a universal sex and anthropomorphic relationship to cerebrospinal fluid.
Normal childhood brain growth and a universal sex and anthropomorphic relationship to cerebrospinal fluid.
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DOI：
10.3171/2021.2.peds201006
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发表时间：
2021-10-01
期刊：
影响因子：
--
通讯作者：
Schiff SJ
中科院分区：
文献类型：
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作者：
Peterson MR;Cherukuri V;Paulson JN;Ssentongo P;Kulkarni AV;Warf BC;Monga V;Schiff SJ
对大脑大小和生长的研究有一个漫长而有争议的历史，但正常的脑容量发育尚未得到充分的描述。特别是，正常的脑生长和脑脊液（CSF）积累关系是表征的关键，因为它在儿童早期的许多情况下受到影响，其中脑生长和液体积累受到影响，如感染、出血、脑积水和广泛的先天性疾病。本研究的作者旨在描述正常的脑容量增长，特别是在脑脊液积累的情况下。作者分析了505名健康儿童从出生到18岁的1067次磁共振成像扫描，以量化脑的组成和区域体积。使用平滑样条方差分析比较两性和半球之间的体积轨迹。人口增长曲线采用广义的位置、规模和形状加性模型。脑容量在10-12岁时达到峰值。男性表现出比女性更大的年龄调整后的总脑容量，并且身体尺寸标准化程序并没有消除这种差异。然而，脑容量与脑脊液容量的比例揭示了一种普遍的年龄依赖关系，与性别或体型无关。这些发现使规范生长曲线能够应用于管理范围广泛的儿童疾病，其中认知发育、大脑生长和体液积聚是相互关联的。
The study of brain size and growth has a long and contentious history, yet normal brain volume development has yet to be fully described. In particular, the normal brain growth and cerebrospinal fluid (CSF) accumulation relationship is critical to characterize because it is impacted in numerous conditions of early childhood in which brain growth and fluid accumulation are affected, such as infection, hemorrhage, hydrocephalus, and a broad range of congenital disorders. The authors of this study aim to describe normal brain volume growth, particularly in the setting of CSF accumulation. The authors analyzed 1067 magnetic resonance imaging scans from 505 healthy pediatric subjects from birth to age 18 years to quantify component and regional brain volumes. The volume trajectories were compared between the sexes and hemispheres using smoothing spline ANOVA. Population growth curves were developed using generalized additive models for location, scale, and shape. Brain volume peaked at 10–12 years of age. Males exhibited larger age-adjusted total brain volumes than females, and body size normalization procedures did not eliminate this difference. The ratio of brain to CSF volume, however, revealed a universal age-dependent relationship independent of sex or body size. These findings enable the application of normative growth curves in managing a broad range of childhood diseases in which cognitive development, brain growth, and fluid accumulation are interrelated.