Alkylating ability of artemisinin after Cu(I)-induced activation
Alkylating ability of artemisinin after Cu(I)-induced activation
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DOI：
10.1007/s00775-009-0474-z
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发表时间：
2009-05-01
影响因子：
3
通讯作者：
Robert, Anne
中科院分区：
文献类型：
--
作者：
Bousejra-El Garah, Fatima;Pitie, Marguerite;Robert, Anne
The reductive activation of artemisinin by copper(I)-dipyrrin or copper(I)-(2-Clip-Phen) complexes generates an artemisinin derived alkylating species leading to covalent artemisinin-copper complex adducts. The reactivity of the peroxide function of artemisinin toward Cu(I) complexes is similar to that of Fe(II) analogues, even though the reaction is more sluggish and product distribution slightly different.
