Relating crack-tip deformation to mineralization and fracture resistance in human femur cortical bone
Relating crack-tip deformation to mineralization and fracture resistance in human femur cortical bone
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DOI：
10.1016/j.bone.2009.01.468
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发表时间：
2009-09-01
期刊：
影响因子：
4.1
通讯作者：
Nicolella, Daniel P.
中科院分区：
文献类型：
--
作者：
Chan, Kwai S.;Chan, Candace K.;Nicolella, Daniel P.
骨折的风险随着年龄的增长而增加，原因有很多，其中包括骨质数量和质量的下降。尽管最近取得了进展，但骨微观结构和微量矿化在骨折过程中的作用尚未得到很好的理解。在这项研究中，我们利用原位断裂韧性测试、数字应变图和x射线光电子能谱技术来表征两个年龄供体（48岁和78岁女性）骨标本的近尖端应变场、断裂韧性和断裂表面的化学元素。我们表明，年龄相关的骨折脆化与较高的近尖端应变有关，这些应变是由年轻骨的板层剪切和板层界面处的裂纹挠曲引起的，而在年老骨中则没有。不同的近尖端变形行为可能与幼骨中Si和Zn含量较高，Ca和P含量较高，而老骨中Si和Zn含量较低有关。(C) 2009爱思唯尔公司版权所有。
The risk of bone fracture increases with age because of a variety of factors that include, among others, decreasing bone quantity and quality. Despite recent advances, the roles of bone microstructure and trace mineralization in the fracture process are not well understood. In this Study, we utilize a combination of in-situ fracture toughness testing, digital strain mapping, and X-ray photoelectron spectroscopy techniques to characterize the near-tip strain field, fracture toughness, and chemical elements on the fracture surface of bone specimens from donors of two ages (48-year-old and 78-year-old females). We show that age-related embrittlement of bone fracture is associated with higher near-tip strains by lamellar shear and crack deflection at lamellar interfaces in the young bone and their absence in the old bone. The different near-tip deformation behaviors may be associated with the presence of Si and Zn in the young bone but more Ca and P and the lack of Si and Zn in the old bone. (C) 2009 Elsevier Inc. All rights reserved.