INTRACELLULAR ALKALOSIS DURING HYPOXIA IN NEWBORN MOUSE-BRAIN IN THE PRESENCE OF SYSTEMIC ACIDOSIS - A PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPIC STUDY
INTRACELLULAR ALKALOSIS DURING HYPOXIA IN NEWBORN MOUSE-BRAIN IN THE PRESENCE OF SYSTEMIC ACIDOSIS - A PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPIC STUDY
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DOI：
10.1016/0387-7604(95)00053-e
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发表时间：
1995-07-01
影响因子：
1.7
通讯作者：
SAWADA, T
中科院分区：
文献类型：
--
作者：
MITSUFUJI, N;YOSHIOKA, H;SAWADA, T
应用磷磁共振波谱技术，连续观察了新生小鼠缺氧8h（FiO（2）= 5%）时脑内能量代谢和pH值的变化。缺氧1h时，脑内pH值（pH（i））由7.20 ± 0.03升高至7.36 ± 0.03（P < 0.05），随后逐渐下降。混合动、静脉血pH值在缺氧过程中逐渐下降，至缺氧结束时达到最低值7.16 ± 0.01，而P-CO_2与对照组无显著差异（47.4 +/- 0.8 mm Hg）和缺氧1小时（49.0 ± 1.1 mm Hg）小鼠，缺氧1 h血糖浓度显著升高，这些结果表明，缺氧期间pH（i）的碱性变化既不是由低碳酸血症引起的全身性水肿也不是由低血糖引起的。
We investigated the in vivo changes in cerebral energy metabolism and pH, in newborn mice noninvasively during 8 h of hypoxia with FiO(2) = 5%, using phosphorus magnetic resonance spectroscopy continuously, The intracellular brain pH (pH(i)) increased from 7.20 +/- 0.03 to 7.36 +/- 0.03 (P < 0.05) at 1 h of hypoxia and then decreased gradually. On the other hand, the mixed arterial and venous blood pH decreased gradually during hypoxia, reaching a minimum value of 7.16 +/- 0.01 at the end of the hypoxia, There was no significant difference in P-CO2 between control (47.4 +/- 0.8 mm Hg) and 1-h hypoxic (49.0 +/- 1.1 mm Hg) mice, The blood glucose concentration was significantly increased at 1 h of hypoxia, These results indicate that the alkaline shift in pH(i) during hypoxia was caused neither by systemic alkalosis due to hypocapnia nor hypoglycemia.