An epidermis-driven mechanism positions and scales stem cell niches in plants.
An epidermis-driven mechanism positions and scales stem cell niches in plants.
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DOI：
10.1126/sciadv.1500989
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发表时间：
2016-01
期刊：
影响因子：
13.6
通讯作者：
Jönsson H
中科院分区：
文献类型：
--
作者：
Gruel J;Landrein B;Tarr P;Schuster C;Refahi Y;Sampathkumar A;Hamant O;Meyerowitz EM;Jönsson H
植物茎干细胞的表皮控制可以解释生态位表达域的规模和位置。在发育生物学中，分子模式如何与器官大小成比例是一个备受争议的问题。我们探讨这个问题的特征基因表达域的植物干细胞龛居住在茎尖分生组织。我们表明，来自表皮细胞层的信号的组合可以正确地图案的关键基因表达域，并显着导致这些域的自适应缩放的组织的大小。使用实时成像，我们实验证实了这一预测。所确定的机制也足以解释新生的干细胞壁龛在新兴的花朵。我们的研究结果表明，变形的组织转置分生组织的几何形状成一个指导性的缩放和位置输入顶端植物干细胞龛。
An epidermis control of plant shoot stem cells can explain the scaling and position of the niche expression domains. How molecular patterning scales to organ size is highly debated in developmental biology. We explore this question for the characteristic gene expression domains of the plant stem cell niche residing in the shoot apical meristem. We show that a combination of signals originating from the epidermal cell layer can correctly pattern the key gene expression domains and notably leads to adaptive scaling of these domains to the size of the tissue. Using live imaging, we experimentally confirm this prediction. The identified mechanism is also sufficient to explain de novo stem cell niches in emerging flowers. Our findings suggest that the deformation of the tissue transposes meristem geometry into an instructive scaling and positional input for the apical plant stem cell niche.