Focal uptake on 18F-fluoro-2-deoxyglucose positron emission tomography images indicates cardiac involvement of sarcoidosis
Focal uptake on 18F-fluoro-2-deoxyglucose positron emission tomography images indicates cardiac involvement of sarcoidosis
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DOI：
10.1093/eurheartj/ehi180
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发表时间：
2005-08-01
影响因子：
39.3
通讯作者：
Nishimura, M
中科院分区：
文献类型：
--
作者：
Ishimaru, S;Tsujino, I;Nishimura, M
目的探讨18氟脱氧葡萄糖正电子发射断层显像（F-18-FDG PET）对心脏结节病的诊断价值。所有受试者在禁食6小时后接受心脏F-18-FDG PET，结节病受试者接受血液检查、ECG、超声心动图和Ga-67和Tc-99 m-m-sestamibi（MIBI）血管造影。我们将F-18-FDG PET图像分为四种模式（“无”、“弥漫”、“局灶性”和“局灶性对弥漫”），发现所有对照受试者均表现出无（n=16）或弥漫（n=14）模式。相反，15例结节病患者无表现，7例表现为弥漫性，8例表现为局灶性，2例表现为局灶性对弥漫性模式，与对照组相比，结节病组中局灶性和局灶性对弥漫性模式的患病率显著较高32例结节病患者Ga-67核素显像均无异常，P=0.001。结论F18-FDG PET心脏局灶性摄取是结节病的特征性表现。此外，F-18-FDG PET有可能检测Ga-67或Tc-99 m-MIBI造影无法诊断的心脏结节病。
Aims To evaluate the value of F-18-fluoro-2-deoxyglucose positron emission tomography (F-18-FDG PET) in detecting cardiac sarcoidosis.Methods and results Thirty-two patients with sarcoidosis and thirty controls were recruited. All subjects underwent cardiac F-18-FDG PET after a 6 h fasting period, and subjects with sarcoidosis underwent blood testing, ECG, echocardiography, and Ga-67 and Tc-99m-sestamibi (MIBI) scintigraphy. We classified F-18-FDG PET images into four patterns ('none', 'diffuse', 'focal', and 'focal on diffuse') and found that all the control subjects exhibited either none (n=16) or diffuse (n=14) pattern. In contrast, fifteen subjects with sarcoidosis exhibited none, seven exhibited diffuse, eight exhibited focal, and two exhibited focal on diffuse patterns, with the prevalence of the focal and focal on diffuse patterns being significantly higher in the sarcoidosis group when compared with the control group (P=0.001), None of the 32 subjects with sarcoidosis exhibited abnormal findings on Ga-67 scintigraphy, and 4 exhibited abnormal findings on Tc-99m-MIBI scintigraphy.Conclusion Focal uptake of the heart on F-18-FDG PET images is a characteristic feature of patients with sarcoidosis. Furthermore, F-18-FDG PET has the potential to detect cardiac sarcoidosis that cannot be diagnosed by Ga-67 or Tc-99m-MIBI scintigraphy.