The skin microbiome and immune system: Potential target for chemoprevention?
The skin microbiome and immune system: Potential target for chemoprevention?
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皮肤微生物组和免疫系统：化学预防的潜在目标？
DOI：
10.1111/phpp.12334
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Yusuf,Nabiha
中科院分区：
文献类型：
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作者：
Sherwani,MohammadAsif;Tufail,Saba;Muzaffar,AnumFatima;Yusuf,Nabiha
人们对了解人类微生物组在皮肤病中的作用越来越感兴趣。微生物组研究正以多种方式用于皮肤癌研究。共生细菌正在被研究作为一种潜在的工具来判断皮肤癌的最大环境风险，紫外线（UV）辐射。由于皮肤微生物在炎症过程中的公认联系，已经有理论将皮肤细菌与皮肤癌联系起来。病毒宏基因组学还提供了对病毒相关形式的皮肤癌的深入了解。可以对皮肤微生物组进行推测，以类似于肠道微生物组的方式，它们可以参与皮肤癌的化学预防。尽管如此，我们对微生物组和皮肤癌之间关系的认识肯定存在巨大差距，特别是在化学预防方面。在皮肤癌研究中利用微生物组似乎是一个有前途的领域，可能有助于产生新的皮肤癌预防和治疗方案。本文综述了微生物组在皮肤癌研究中的最新应用，并探讨了利用微生物组预防、早期诊断和治疗皮肤癌的潜力。
There has been increasing interest in understanding the role of the human microbiome in skin diseases. Microbiome studies are being utilized in skin cancer research in numerous ways. Commensal bacteria are being studied as a potential tool to judge the biggest environmental risk of skin cancer, ultraviolet (UV) radiation. Owing to the recognized link of skin microbes in the process of inflammation, there have been theories linking commensal bacteria to skin cancer. Viral metagenomics has also provided insight into virus linked forms of skin cancers. Speculations can be drawn for skin microbiome that in a manner similar to gut microbiome, they can be involved in chemoprevention of skin cancer. Nonetheless, there are definitely huge gaps in our knowledge of the relationship of microbiome and skin cancers, especially in relation to chemoprevention. The utilization of microbiome in skin cancer research seems to be a promising field and may help yield novel skin cancer prevention and treatment options. This review focuses on recent utilization of the microbiome in skin cancer research, and it explores the potential of utilizing the microbiome in prevention, earlier diagnosis, and treatment of skin cancers.