Cutting edge:: Activation of toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma
Cutting edge:: Activation of toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma
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DOI：
10.4049/jimmunol.172.5.2739
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发表时间：
2004-03-01
影响因子：
4.4
通讯作者：
Raz, E
中科院分区：
文献类型：
--
作者：
Redecke, V;Häcker, H;Raz, E
APC对微生物组分的识别及其通过Toll样受体（TLR）的活化导致诱导适应性免疫应答。在这项研究中，我们表明，激活TLR 2的合成配体Pam 3Cys，在相反的TLR 9的免疫刺激DNA（ISS-ODN）的激活，诱导一个突出的Th 2偏向的免疫反应。通过Pam 3Cys激活APC导致诱导Th 2相关效应分子如IL-13和IL-1 β、GM-CSF和上调B7 RP-1，但低水平的Th 1相关细胞因子（IL-12、IFN α、IL-18、IL-27）。因此，TLR 2配体加重实验性哮喘。这些数据表明，在免疫激活的初始阶段TLR刺激的类型决定了适应性免疫反应的极化，并可能在Th 2介导的免疫疾病，如哮喘的启动中发挥作用。
Recognition of microbial components by APCs and their activation through Toll-like receptors (TLR) leads to the induction of adaptive immune responses. In this study, we show that activation of TLR2 by its synthetic ligand Pam3Cys, in contrast to activation of TLR9 by immunostimulatory DNA (ISS-ODN), induces a prominent Th2-biased immune response. Activation of APCs by Pam3Cys resulted in the induction of Th2-associated effector molecules like IL-13, and IL-1beta, GM-CSF and up-regulation of B7RP-1, but low levels of Th1-associated cytokines (IL-12, IFNalpha, IL-18, IL-27). Accordingly, TLR2 ligands aggravated experimental asthma. These data indicate that the type of TLR stimulation during the initial phase of immune activation determines the polarization of the adaptive immune response and may play a role in the initiation of Th2-mediated immune disorders, such as asthma.