ELEVATED QUANTITATIVE VIBROTACTILE THRESHOLD AMONG WORKERS PREVIOUSLY POISONED WITH METHAMIDOPHOS AND OTHER ORGANOPHOSPHATE PESTICIDES
ELEVATED QUANTITATIVE VIBROTACTILE THRESHOLD AMONG WORKERS PREVIOUSLY POISONED WITH METHAMIDOPHOS AND OTHER ORGANOPHOSPHATE PESTICIDES
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DOI：
10.1002/ajim.4700250303
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发表时间：
1994-03-01
影响因子：
3.5
通讯作者：
ROSENSTOCK, L
中科院分区：
文献类型：
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作者：
MCCONNELL, R;KEIFER, M;ROSENSTOCK, L
为了评估急性有机磷农药中毒的慢性影响，定量测定了振动触觉阈值作为尼加拉瓜农业工人周围神经病变的指标。36名男性工人在急性有机磷中毒住院10至34个月期间进行了评估，并与年龄和性别匹配的社区参照组进行了比较。定量测量左右食指和左右大脚趾的振动触觉阈值。研究对象分为三组：1)未中毒；2)甲胺磷以外的有机磷中毒，未见引起周围神经病变的报道；3)甲胺磷中毒，这是一种周围神经毒素。对于所有数字，在这三种暴露类别中，年龄和身高调整阈值都有统计学上显著的增加趋势。在我们研究的甲胺磷中毒患者中，超过四分之一的人有异常的振动触觉阈值。这些结果表明，以前报道的有机磷诱导的延迟性多神经病变病例可能只代表了一系列损害中最严重的疾病，暴露的后遗症可能比以前认为的要常见得多。(C) 1994 Wiley-Liss, Inc。
To evaluate chronic effects of acute organophosphate pesticide poisoning, quantitatively determined vibrotactile thresholds were measured as an index of peripheral neuropathy among agricultural workers in Nicaragua. Thirty-six male workers were evaluated between 10 and 34 months after hospitalization for acute organophosphate poisoning and compared to an age- and sex-matched community reference group. Vibrotactile thresholds were measured quantitatively in right and left index fingers and right and left great toes. Study subjects were stratified into three groups: 1) never poisoned; 2) poisoned with organophosphates other than methamidophos, agents which have not been reported to cause peripheral neuropathy; and 3) poisoned with methamidophos, a peripheral neurotoxin. For all digits, there was a statistically significant trend of increasing age- and height-adjusted thresholds across these three exposure categories. Over one fourth of patients previously poisoned with methamidophos we studied had abnormal vibrotactile thresholds. These results suggest that previously reported cases of organophosphate-induced delayed polyneuropathy may represent only the worst disease in a spectrum of impairment, a sequela of exposure that may be much more common than previously thought. (C) 1994 Wiley-Liss, Inc.