Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-1 levels and bowel movement frequency and negatively with systolic blood pressure
Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-1 levels and bowel movement frequency and negatively with systolic blood pressure
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DOI：
10.1677/joe.1.06442
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发表时间：
2006-02-01
影响因子：
4
通讯作者：
Kangawa', K
中科院分区：
文献类型：
--
作者：
Akamizu, T;Murayama, T;Kangawa', K
衰老与生长激素（GH）分泌、食欲和能量摄入的减少有关。由于生长激素释放肽刺激GH分泌和食欲，生长激素释放肽水平的降低可能涉及在老年人中观察到的GH分泌和食欲的减少。然而，只有初步的研究已经进行油ghrelin在老年受试者中的作用。在这项研究中，我们试图通过测定健康老年受试者的血浆ghrelin水平和其他临床参数来阐明ghrelin分泌与年龄相关的变化的生理意义。受试者年龄≥ 65岁，符合SENIEUR方案，未接受过上消化道切除术，也未接受过激素治疗。本研究共招募了105名志愿者（49名男性和56名女性）（73.4 +/- 16.3岁）。老年女性受试者血浆酰化ghrelin水平与血清IGF-I水平和排便频率呈正相关，与收缩压呈负相关。在老年男性中，去酰基ghrelin水平与排便频率仅弱相关。这些发现表明，血浆中酰化形式的ghrelin的水平可能会影响GH/IGF-I调节，血压和肠动力的年龄相关的变化。这些观察到的相关性需要进一步的实验研究来阐明这些效应的生理学意义。
Aging is associated with a decrease in growth hormone (GH) secretion, appetite and energy intake. As ghrelin stimulates both GH secretion and appetite, reductions in ghrelin levels may be involved in the reductions in GH secretion and appetite observed in the elderly. However, only preliminary studies have been performed oil the role of ghrelin in elderly subjects. In this study, we sought to clarify the physiologic implications of the age-related alterations in ghrelin secretion by determining plasma ghrelin levels and other clinical parameters ill healthy elderly subjects. Subjects were >= 65 years old, corresponding to the SENIEUR protocol, had not had a resection of the upper gastrointestinal tract and had not been treated with hormones. One hundred and five volunteers (49 men and 56 women) were admitted to this study (73.4 +/- 16.3 years old). Plasma levels of acylated ghrelin in elderly female subjects positively correlated with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure. In elderly men, desacyl ghrelin levels correlated only weakly with bowel movement frequency. These findings suggest that the plasma levels of the acylated form of ghrelin may influence the age-related alterations in GH/IGF-I regulation, blood pressure and bowel motility. These observational associations warrant further experimental Studies to clarify, the physiologic significance of these effects.