Reference Genome Anchoring of High-Density Markers for Association Mapping and Genomic Prediction in European Winter Wheat
Reference Genome Anchoring of High-Density Markers for Association Mapping and Genomic Prediction in European Winter Wheat
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DOI：
10.3389/fpls.2019.01278
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发表时间：
2019-11-08
影响因子：
5.6
通讯作者：
Bentley, Alison R.
中科院分区：
文献类型：
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作者：
Ladejobi, Olufunmilayo;Mackay, Ian J.;Bentley, Alison R.
在这项研究中，我们将基因分型测序数据锚定到国际小麦基因组测序联盟参考序列v1.0汇编中，在1946年至2007年间发布的376个欧洲优质冬小麦品种中产生了超过40,000个高质量的单核苷酸多态性标记。我们将一系列生产力性状的关联图谱和基因组预测精度与先前基于低密度优势DArT标记的结果进行了比较。结果表明，RefSeq v1.0的可用性支持更高精度的性状定位，并提供所需的标记密度，以获得由多个小效应位点控制的性状的准确预测，包括粮食产量。
In this study, we anchored genotyping-by-sequencing data to the International Wheat Genome Sequencing Consortium Reference Sequence v1.0 assembly to generate over 40,000 high quality single nucleotide polymorphism markers on a panel of 376 elite European winter wheat varieties released between 1946 and 2007. We compared association mapping and genomic prediction accuracy for a range of productivity traits with previous results based on lower density dominant DArT markers. The results demonstrate that the availability of RefSeq v1.0 supports higher precision trait mapping and provides the density of markers required to obtain accurate predictions of traits controlled by multiple small effect loci, including grain yield.